1.0 2018-05-07 22:29:35 UTC 2020-05-20 21:07:58 UTC BMDBP02005 Enzyme PUF60 Involved in DNA binding DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA (By similarity). BMDB0003361 Pyrimidine 14 >1593 bp ATGGCGACGGCGACCATAGCGCTAGGGACAGACTCCATCAAGATGGAGAACGGGCAGGGC ACAGCCGCGAAGCTGGGACTGCCTCCCTTGACGCCCGAGCAGCAGGAGGCCCTCCAGAAG GCCAAGAAGTACGCCATGGAGCAGAGCATCAAGAGCGTGCTGGTGAAACAGACCATCGCC CACCAGCAGCAGCAGCTTACCAACCTGCAGATGGCAGCAGTGACAATGGGCTTTGGAGAT CCTCTCTCACCTTTGCAATCGATGGCGGCTCAGCGGCAGCGGGCACTGGCCATCATGTGC CGGGTCTACGTGGGCTCCATCTACTACGAGCTAGGGGAGGACACCATCCGCCAGGCGTTC GCCCCCTTTGGGCCTATCAAGAGCATCGACATGTCCTGGGACTCCGTCACCATGAAGCAC AAGGGCTTTGCGTTTGTGGAGTATGAGGTCCCAGAAGCCGCCCAGCTGGCCTTGGAGCAG ATGAATTCCGTGATGCTGGGAGGCAGGAACATCAAGGTGGGCAGACCCAGCAACATAGGG CAGGCTCAGCCCATCATAGACCAGCTGGCCGAGGAGGCGCGAGCCTTCAACCGCATCTAC GTGGCTTCCGTGCACCAGGACCTCTCGGATGATGACATCAAGAGTGTGTTTGAGGCCTTT GGCAAGATCAAATCCTGCACGCTGGCTCGGGACCCCACGACTGGCAAACACAAGGGCTAT GGCTTCATTGAATATGAGAAAGCCCAATCGTCCCAGGATGCTGTGTCTTCCATGAACCTT TTTGACCTGGGGGGCCAGTACTTGCGGGTGGGCAAGGCTGTCACACCCCCTATGCCCCTG CTTACACCGGCCACACCTGGAGGCCTCCCGCCGGCTGCTGCCGTGGCCGCAGCTGCAGCC ACAGCCAAGATTACAGCTCAGGAAGCAGTGGCTGGAGCAGCAGTACTGGGTACCCTAGCC ACTCCTGGACTGGTGTCCCCTGCACTGACTCTGGCCCAGCCCCTGGGGGCTCTACCCCAG GCCGTCATGGCTGCCCAGGCCCCAGGAGTCATCACAGGTGTGACACCGGCTCGGCCTCCC ATTCCGGTCACCATCCCCTCTGTTGGTGTGGTGAATCCCATCCTGGCCAGCCCTCCGACA CTTGGTCTCCTGGAGCCTAAGAAGGAGAAGGAGGAGGAGGAGCTGTTTCCCGAGTCGGAG CGGCCGGAGATGCTGAGTGAGCAGGAGCACATGAGCATCTCAGGAAGCAGCGCCCGCCAC ATGGTGATGCAGAAGCTCCTCCGCAAGCAGGAGTCCACAGTGATGGTTCTGCGTAACATG GTGGACCCCAAGGACATCGACGATGACCTTGAAGGGGAGGTGACTGAGGAGTGTGGCAAG TTTGGTGCTGTCAACCGTGTCATCATCTACCAAGAGAAGCAGGGCGAGGAAGAGGACGCG GAGATCATTGTCAAGATTTTTGTGGAGTTTTCCGTAGCCTCTGAGACTCACAAGGCCATC CAGGACCTCAATGGGCGCTGGTTTGCTGGCCGCAAGGTGGTGGCTGAAGTGTATGACCAG GAGCGTTTTGATAACAGTGACCTCTCTGCATGA 530 57087.0 4.87 None >Poly(U)-binding-splicing factor PUF60 MATATIALGTDSIKMENGQGTAAKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIA HQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAF APFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIG QAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGY GFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAA TAKITAQEAVAGAAVLGTLATPGLVSPALTLAQPLGALPQAVMAAQAPGVITGVTPARPP IPVTIPSVGVVNPILASPPTLGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARH MVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDA EIIVKIFVEFSVASETHKAIQDLNGRWFAGRKVVAEVYDQERFDNSDLSA AAI05448.1 Q2HJG2 PUF60_BOVIN BC105447 PUF60