1.0 2018-05-07 22:29:35 UTC 2020-05-20 21:09:45 UTC BMDBP02006 Enzyme U2AF1L4 Involved in nucleotide binding RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). BMDB0003361 Pyrimidine 18 >663 bp ATGGCTGAATATTTAGCATCGATATTCGGGACTGAGAAGGACAAGGTTAACTGCTCTTTT TACTTTAAGATCGGGGCCTGCCGGCACGGGGACCGGTGCTCCCGGCTTCACAACAAGCCG ACTTTCAGCCAGACCATAGTGCTGCTCAACCTGTATCGGAATCCACAGAACACCGCCCAA ACCGCAGACGGATCTCACTGTCACGTGAGCGACGTGGAGGTGCAAGAACACTATGATAAC TTCTTCGAGGAAGTGTTCACCGAACTGCAGGAGAAGTACGGGGAGATTGAAGAGATGAAT GTGTGCGACAACCTGGGGGACCACCTCGTGGGCAATGTTTATGTCAAGTTTCGGCGTGAG GAAGATGCAGAGCGGGCAGTGGTTGAGCTCAATAACCGCTGGTTCAACGGGCAAGCTGTG CATGCTGAGCTGTCTCCCGTCACCGATTTCCGGGAGTCGTGCTGTCGGCAGTATGAGATG GGGGAATGTACCCGCGGTGGTTTCTGCAACTTCATGCACCTGCGACCCATTTCCCGAGAC CTCCGGCGGCAGCTCTACGGGCGGGGACCCAGGCGCAGGTCACCCCCAAGGTCCCATACT GGCCACCGTCCCCGAGAAAGAAATCGACGACGGTCTCCAGACCACCGGCATGGTCGTTTC TGA 220 25884.0 8.17 None >Splicing factor U2AF 26 kDa subunit MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIVLLNLYRNPQNTAQ TADGSHCHVSDVEVQEHYDNFFEEVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRRE EDAERAVVELNNRWFNGQAVHAELSPVTDFRESCCRQYEMGECTRGGFCNFMHLRPISRD LRRQLYGRGPRRRSPPRSHTGHRPRERNRRRSPDHRHGRF AAI02152.1 Q3T127 U2AF4_BOVIN BC102151 U2AF1L4