| Identification |
|---|
| BMDB Protein ID
| BMDBP02035 |
| Secondary Accession Numbers
| None |
| Name
| Oxidized low-density lipoprotein receptor 1 |
| Synonyms
|
Not Available
|
| Gene Name
| OLR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| OLR1 |
| Gene Sequence
|
>813 bp
ATGACTGTTGATGACCCCAAGGGTATGAAAGATCAACTTGATCAGAAGCCAAATGGCAAG
ACAGCAAAAGGTTTTGTTTCCTCTTGGAGGTGGTACCCTGCTGCTGTGACTCTAGGGGTC
CTTTGTCTGGGATTACTGGTGACTGTTATATTGTTGATACTGCAATTATCCCAGGTCTCT
GATCTCATAAAGAAACAGCAAGCAAATATTACTCACCAGGAAGATATCCTGGAGGGACAG
ATTTTAGCCCAGCGCCGATCAGAAAAATCTGCCCAGGAGTCACAGAAGGAACTCAAAGAA
ATGATAGAAACCCTTGCCCACAAGCTGGATGAGAAATCCAAGAAACTAATGGAACTTCAC
CGCCAGAACCTGAATCTCCAAGAAGTTCTGAAAGAGGCAGCAAACTATTCAGGTCCTTGT
CCCCAAGACTGGCTCTGGCATGAAGAAAACTGTTACCAATTTTCCTCTGGCTCTTTTAAT
TGGGAAAAAAGCCAGGAGAACTGCTTGTCTTTGGATGCCCACTTGCTGAAGATTAATAGC
ACAGATGAACTGGAATTCATCCAGCAAATGATTGCCCATTCCAGTTTCCCCTTCTGGATG
GGGTTGTCAATGAGGAAACCCAATTACTCGTGGCTTTGGGAAGATGGTACTCCTTTGACG
CCCCACTTGTTTAGAATTCAGGGAGCTGTTTCCCGTATGTATCCTTCAGGGACCTGTGCA
TATATTCAAAGGGGAACTGTTTTTGCTGAAAACTGCATTTTAACTGCATTCAGTATATGT
CAAAAGAAGGCGAATCTATTGAGAGCACAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 270 |
| Molecular Weight
| 30892.0 |
| Theoretical pI
| 7.14 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Oxidized low-density lipoprotein receptor 1
MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVS
DLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELH
RQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINS
TDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCA
YIQRGTVFAENCILTAFSICQKKANLLRAQ
|
| External Links |
|---|
| GenBank ID Protein
| BAA19005.1 |
| UniProtKB/Swiss-Prot ID
| P79391 |
| UniProtKB/Swiss-Prot Entry Name
| OLR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D89049 |
| GeneCard ID
| OLR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
