| Identification |
|---|
| BMDB Protein ID
| BMDBP02096 |
| Secondary Accession Numbers
| None |
| Name
| Polyglutamine-binding protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PQBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| PQBP1 |
| Gene Sequence
|
>792 bp
ATGCCGCTGCCCGTTGCGTTGCAGACCCGCTTGGCCAAGAGAGGCATCCTCAAACATTTG
GAGCCTGAACCAGAGGAAGAGATCATTGCTGAGGACTATGACGATGATCCTGTGGACTAT
GAGGCTACCCGGTTGGAGGGCCTGCCACCAAGCTGGTACAAGGTGTTTGACCCTTCCTGC
GGACTTCCTTACTACTGGAATGTGGACACAGACCTTGTGTCCTGGCTTTCCCCACATGAC
CCCAACTCTGTTGTTACCAAATCTGCCAAGAAGCTCAGGAGCAGTAATGCAGACGCTGAG
GAGAAGCTGGATCGGAGCCATGAGAAATCAGACCGTGGCCACGAGAAATCGGACCGAGGT
CATGAGAAGTCAGACCGCAGCCATGAGAAGTCAGAGCGGAACCATGAGAAGTCTGACAGG
GACCGGGAGCGTGGTTATGACAAGGTAGATAGAGAGAGAGAGCGAGACCGGGACCGGGAC
CGTGGGTATGACAAGGTCGACCGAGAAGAGAGCAAAGAACGGCGCCATCATCGCCGGGAG
GAGCTGGCTCCCTACCCCAAGAGCAAGAAGGCAGCAAGCCGAAAGGATGAAGAATTAGAC
CCCATGGACCCCAGCTCATACTCAGATGCACCCCGGGGCACGTGGTCAACAGGACTCCCC
AAGCGGAATGAGGCCAAGACAGGTGCAGACACGACAGCAGCTGGGCCCCTCTTCCAGCAG
CGCCCTTACCCCTCCCCAGGGGCTGTTCTCCGGGCCAATGCCGAGGCCTCCCGAACCAAG
CAGCAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 263 |
| Molecular Weight
| 30346.0 |
| Theoretical pI
| 6.26 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Polyglutamine-binding protein 1
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSC
GLPYYWNVDTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHEKSDRGHEKSDRG
HEKSDRSHEKSERNHEKSDRDRERGYDKVDRERERDRDRDRGYDKVDREESKERRHHRRE
ELAPYPKSKKAASRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQ
RPYPSPGAVLRANAEASRTKQQD
|
| External Links |
|---|
| GenBank ID Protein
| AAI05574.1 |
| UniProtKB/Swiss-Prot ID
| Q2HJC9 |
| UniProtKB/Swiss-Prot Entry Name
| PQBP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105573 |
| GeneCard ID
| PQBP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
