| Identification |
|---|
| BMDB Protein ID
| BMDBP02110 |
| Secondary Accession Numbers
| None |
| Name
| 24-dehydrocholesterol reductase |
| Synonyms
|
Not Available
|
| Gene Name
| DHCR24 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Not Available |
| Pathways
|
|
| Reactions
|
| Lanosterin + NADPH → 24,25-Dihydrolanosterol + NADP |
details
|
| 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADPH → 4,4-Dimethyl-5a-cholesta-8-en-3b-ol + NADP |
details
|
| Zymosterol intermediate 2 + NADPH → 5a-Cholest-8-en-3b-ol + NADP |
details
|
| 5a-Cholesta-7,24-dien-3b-ol + NADPH → Lathosterol + NADP |
details
|
| 7-Dehydrodesmosterol + NADPH → 7-Dehydrocholesterol + NADP |
details
|
| Desmosterol + NADPH → Cholesterol + NADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| DHCR24 |
| Gene Sequence
|
>1551 bp
ATGGAGCCCGCTGTGTCGCTGGCCGTGTGCGCGCTGCTCTTCCTGCTCTGGGTTCGGGTG
AAGGGGCTGGAGTTCGTTCTCATCCACCAGCGCTGGGTGTTTGTGTGCCTCTTCCTCCTA
CCTCTCTCGCTCATCTTCGACATCTACTACTACGTGCGCGCCTGGGTGGTGTTCAAGCTC
AGCAGCGCACCGCGGCTGCACGAACAGCGCGTGCGGGACATCCAGAAACAGGTGCGGGAA
TGGAAGGAGCAGGGCAGCAAGACCTTCATGTGCACGGGGCGACCTGGCTGGCTCACTGTT
TCACTGCGGGTTGGGAAGTACAAGAAGACACACAAAAACATAATGATCAACCTGATGGAC
ATTCTGGAGGTGGACACCAAGAAACAGATTGTCCGAGTGGAGCCCTTGGTGACCATGGGT
CAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTGCCTGTGTTGCCCGAGCTGGAT
GACCTCACAGTGGGAGGACTGATCATGGGCACAGGCATCGAGTCTTCGTCCCATAGGTAT
GGCTTGTTCCAGCACATCTGCACCGCCTATGAGCTGGTCTTGGCTGATGGCAGCTTTGTG
CGATGTACACCGATGGAAAACTCAGACCTGTTCTACGCTGTGCCCTGGTCCTGCGGGACT
CTGGGCTTCCTGGTGGCTGCCGAGATCCGCATCATCCCTGCCAAGAAGTACATCAAGCTG
CGGTTTGAGCCGGTGCGCGGCCTGGAGGCCATCTGTGACAAGTTCACCCACGAGTCCCAG
CAGCCGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCTCTGCACGAGGCCGTCATCATG
ACGGGGGTCATGACGGACGAGGCAGAGCCCAGCAAGCTGAACAGCATTGGCAACTACTAC
AAGCCCTGGTTCTTCAAGCACGTGGAGAACTACCTGAAGACAAACCGAGAGGGCCTGGAG
TACATCCCCTTGAGACACTACTATCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAG
GACATCATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGTTGGATGGTGCCT
CCCAAGATCTCCCTGCTGAAGCTGACCCAGGGCGAGACGCTGCGCAAGCTGTACGAGCAG
CACCACGTGGTACAGGACATGCTGGTGCCCATGAAGTGCCTGCCGCAGGCCCTGCACACC
TTCCACAACGACATCCACGTCTACCCCATCTGGCTGTGCCCATTCATCCTGCCCAGCCAG
CCGGGCCTGGTGCACCCCAAGGGAGATGAGGCCGAGCTCTATGTCGATATCGGTGCCTAC
GGGGAGCCACGTGTGAAGCATTTTGAAGCCCGGTCCTGCATGAGGCAGTTGGAGAAGTTT
GTCCGAAGTGTGCACGGGTTCCAGATGCTGTATGCCGACTGCTACATGGACCGGGAGGAG
TTCTGGGAGATGTTCGACGGCTCCCTGTACCACAGGCTGCGGAAGCAGCTCGGCTGCCAG
GATGCCTTCCCTGAGGTCTACGACAAGATCTGCAAGGCTGCCAGGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 516 |
| Molecular Weight
| 60173.0 |
| Theoretical pI
| 8.02 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>DHCR24 protein
MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKL
SSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMD
ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHRY
GLFQHICTAYELVLADGSFVRCTPMENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYIKL
RFEPVRGLEAICDKFTHESQQPENHFVEGLLYSLHEAVIMTGVMTDEAEPSKLNSIGNYY
KPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVP
PKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLPQALHTFHNDIHVYPIWLCPFILPSQ
PGLVHPKGDEAELYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMDREE
FWEMFDGSLYHRLRKQLGCQDAFPEVYDKICKAARH
|
| External Links |
|---|
| GenBank ID Protein
| AAI50074.1 |
| UniProtKB/Swiss-Prot ID
| A6QR14 |
| UniProtKB/Swiss-Prot Entry Name
| A6QR14_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC150073 |
| GeneCard ID
| DHCR24 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
