| Identification |
|---|
| BMDB Protein ID
| BMDBP02134 |
| Secondary Accession Numbers
| None |
| Name
| Scavenger receptor class B member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SCARB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in receptor activity |
| Specific Function
| Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| SCARB1 |
| Gene Sequence
|
>1530 bp
ATGGGCAACCTCTCTAGAGCGCGCCGGGTGACCGCGGCGCTGGGTTTCATCGGGCTCCTC
TTCGCCGTGCTGGGCATTATCATGATCGTGATGGTGCCCTCAATCATCAAGCAGCAGGTC
CTCAAGAATGTGCGCATCGACCCCAACAGCCTGTCTTTCAACATGTGGAAGGAAATCCCT
GTCCCCTTCTACCTCTCTGTCTACTTTTTCAACATCGTCAACCCTGAGGGGATCATCCAA
GGCCAGAAGCCACAGGTGCAGGAGCACGGGCCTTATGTGTACAGGGAGTTCAGGCACAAG
AGCAACATCACCTTCAACAACAATGACACGGTGTCCTTCCTGGAGTACCGCAGCTACCAG
TTCCAGCCGGATAAGTCCCGCGGCCAGGAGAGCGACTACATCGTCATGCCCAACATCCTG
GTCTTGAGTGCGTCAATGATGATGGAGAACAGGCCCGGGCTCTTGAAGCTGATGATGACC
TTGGCGTTCAGCACGCTTGGCCAGCGTGCCTTCATGAACCGCACTGTTGGCGAGATCATG
TGGGGCTATGATGACCCCTTAATCCACCTCATCAATCAGTACTTCCCAAACTCGCTCCCC
TTCAAGGGCAAGTTCGGCTTATTTGCTGAGCTCAACAACTCCGATTCTGGCCTCTTCACC
GTGTTCACAGGGGTCAAAAACTTCAGCAGGATCCATCTCGTGGACAAGTGGAATGGAGTC
AGCAAGGTCAACTATTGGCATTCCGATCAGTGCAACATGATTAACGGAACTTCCGGGCAG
ATGTGGGCACCATTTATGACCCCTGAATCCTCGCTGGAATTTTACAGCCCTGAGGCCTGC
CGGTCCATGAAGCTCGTCTACAAGGAGCAGGGGGTGTTTGGAGGCATCCCCACCTTTCGC
TTCGTGGCTCCCAGCACCTTATTTGCCAACGGGTCCGTCTACCCGCCCAACGAGGGCTTC
TGCCCCTGCCGGGAGTCCGGAATCCAAAACGTCAGCACCTGCAGGTTCAATGCGCCCTTG
TTTCTCTCCCATCCTCACTTCTACAACGCTGACCCAGTCCTGGCAGAGGCAGTGTCTGGC
CTCCATCCTAACCCAAAAGAACATTCCTTGTTCCTGGACATCCACCCGGTCACCGGAATC
CCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTTCGTTAAGTCTGTGAAAGGCATC
GGACAAACTGGGAACATCCAGCCAGTGGTCCTGCCGCTAATGTGGTTCGAAGAGAGTGGA
GCAATGGAGGGTGAGACCCTTGAGACGTTCTATATCCAGCTGGTGTTGATGCCCAAAGTG
CTACACTATGCCCAGTATGTGCTCCTTGCCCTGGGCTGCGTCCTACTGCTCATCCCCATC
ATCTACCAAATCCGGAGCCAAGAGAAATGCTATTTATTTTGGATTAGTTTTAAAAAGGGC
TCAAAGGATAAGGAGGCCGTTCAGGCCTATTCTGAATTCCTGATGACATCAGCTCCCAAG
GGAACTGTACTGCAAGAAGCAAGACTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 57610.0 |
| Theoretical pI
| 8.51 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Scavenger receptor class B member 1
MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIP
VPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQ
FQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIM
WGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGV
SKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFR
FVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSG
LHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESG
AMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQEKCYLFWISFKKG
SKDKEAVQAYSEFLMTSAPKGTVLQEARL
|
| External Links |
|---|
| GenBank ID Protein
| AAB70920.1 |
| UniProtKB/Swiss-Prot ID
| O18824 |
| UniProtKB/Swiss-Prot Entry Name
| SCRB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF019384 |
| GeneCard ID
| SCARB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
