| Identification |
|---|
| BMDB Protein ID
| BMDBP02170 |
| Secondary Accession Numbers
| None |
| Name
| Calcium-activated potassium channel subunit beta-1 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNMB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in potassium ion transport |
| Specific Function
| Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| KCNMB1 |
| Gene Sequence
|
>576 bp
ATGGGAAAGAAGCTGGTGATGGCCCAGAGGCGGGGAGAGACTCGGGCCCTCTGCCTGGGG
GTGGCCATGGTCGTGGGCGCCGTCATCACCTACTACATCTTAGGCACAACTGTGCTGCCC
CTCTATCAGAAGAGTGTGTGGACCCAGGAATCCACGTGTCACCTGATTGAGACCAACATC
AGGGACCAGGAGGAGCTGGAGGGCAAGAGGGTGCCCCAGTACCCATGCCTGTGGGTCAAC
GTGTCGTCCGTGGGCCGCTGGGCTGTGCTGTACCACACGGAGGACACGCGGGACCAGAAC
CACCAGTGCTCCTACATCCCAAGCAGCCTGGACAACTACCAAGTGGCCCGGGCCGACGTG
GAGAAGGTCAGAGCCAGGTTCCACGAGAACCAGGATTTCTTCTGCTTCTCCACGACTCGG
GAGAATGAGACCAGCGTCCTGTACCGGCGCCTCTATGGGCCCCAGAGCCTCCTCTTCTCT
CTCTTCTGGCCCACCTTTCTGCTGACTGGCGGCCTGCTCATCATTGTCATGGTGAAGATC
AACCAGTCCCTGTCCATCCTGGCGGCCCAGAGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 191 |
| Molecular Weight
| 21957.0 |
| Theoretical pI
| 8.46 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-activated potassium channel subunit beta-1
MGKKLVMAQRRGETRALCLGVAMVVGAVITYYILGTTVLPLYQKSVWTQESTCHLIETNI
RDQEELEGKRVPQYPCLWVNVSSVGRWAVLYHTEDTRDQNHQCSYIPSSLDNYQVARADV
EKVRARFHENQDFFCFSTTRENETSVLYRRLYGPQSLLFSLFWPTFLLTGGLLIIVMVKI
NQSLSILAAQR
|
| External Links |
|---|
| GenBank ID Protein
| AAA21741.1 |
| UniProtKB/Swiss-Prot ID
| Q28067 |
| UniProtKB/Swiss-Prot Entry Name
| KCMB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L26101 |
| GeneCard ID
| KCNMB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
