1.0 2018-05-07 22:30:22 UTC 2020-05-20 21:05:59 UTC BMDBP02173 Enzyme SCNN1A Involved in amiloride-sensitive sodium channel activity Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. BMDB0000588 Sodium BMDB0002111 Water 5 >1953 bp ATGAAGGGAGACAAGCCTGAGGAGCCGGGGCCGGGTCCCGAGCCTTCGGGCCCCCCGCCG CCCACGGAGGAGGAGGAGGCCCTGCTCGAGTTCCACCGCTCCTACCGGGAGCTCTTCGAG TTCTTCTGCAATAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCGCAGCACAAT CGCATGAAGACAGTCTTCTGGGCCGTGCTCTGGCTCTGCACCTTCGGCATGATGTACTGG CAGTTCGGCCAGCTCTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTC AACTCGGACAAGCTTGTCTTCCCTGCGGTCTCCATCTGCACCCTAAACCCCTACAGGTAC AAGGAAATTCAAGAGGAGCTGGAGGAGCTGGACCGCATCACGGAGCAGACTCTTTTCGAC CTGTACAAGTACAACTCCTCCAAGACCCTCGTGGCCCACGCCCGCTCCCGCCGCGACCTG CGGGAGCCGCTGCCGCACCCCCTTCAGCGCCTGCCCGTCCCGGCTCCGCCCCACGCGGCC CGCGGAGTCCGCCGCGCCGGCTCCAGCATGCGGGACAACAACCCCCAGGTGAACAGGAAG GACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACG TACTCGTCAGGGGTGGATGCTGTGAGAGAGTGGTACCGCTTCCACTACATCAACATTCTG TCCAGACGGAGACAGGACACCTCTCCCTCGCTGGAGGAGGACGTGCTGGGCAAATTCATC TTCACCTGCCGCTTCAACCAGGACTCCTGCAATGAGGCGAATTACTCTCATTTCCACCAC CCGATGTATGGAAACTGCTACACTTTCAACGACAAGAACAGCTCCAACCTCTGGATGTCC TCCATGCCCGGGGTCAACAACGGTCTGTCCCTGACACTGCGCACAGAGCAAAATGACTTC ATCCCACTGCTGTCCACGGTGACCGGGGCCCGGGTGATGGTGCATGAACGGGATGAGCCT GCCTTTATGGATGATGCTGGCTTTAATCTGCGGCCTGGCGTGGAGACCTCCATCAGCATG AGTAAGGAAGCTGTGGACAGACTTGGGGGTGACTATGGCGACTGCACCAAGAATGGCAGC GAGGTCCCAGTGGAGAACCTTTACAATACCAAGTACACGCAGCAGGTGTGCATCCATTCG TGCTTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTACCCGCGGCCC GACGGCGTAGAGTTCTGTGACTACAGGAAGCATAATTCCTGGGGCTACTGCTACTATAAG CTCCAGGATGCCTTCTCCTCAGACCGCCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGC AGTGTGACCATCTACAAGCTCTCTGCCAGTTACTCACAATGGCCGTCCGCGACATCCCAG GACTGGGTCTTCCAGATGCTGTCCCGACAGAACAACTACACCATCAAGAACAAAAGGGAT GGAGTTGCCAAACTCAACATCTTCTTCAAGGAGCTGAACTACAAATCTAATTCTGAGTCT CCCTCAGTCACGATGGTCACGCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTC GGCTCCTCCGTGCTGTCCGTGGTGGAGATGGCTGAGCTCATCATTGACCTCCTGGTTATC ACCTTCCTCATGCTGCTCCGGAGGTTCCGAAGCCGATACTGGTCCCCAGGCCGAGGGGGC AAGGGCACCCAGGAGGTGGCCTCCACTCCAGCCGCCTCCCTCCCCTCCAGTTTCTGCCCC CACCCAGCTTTCTTCTCCTCATCCCCGCCAGACCCTGCCATCTCCCCGGCCTTGTCAGCC CCTCCACCTGCCTATGCCACCCTGGGCCCCCACCCAGCTCCATCAGGCTTGGCAGAGGCC AGCACCTCTGCCCACGCTCCGGGGGAGCCCTGA 650 73793.0 7.16 66-86 544-564 None >Amiloride-sensitive sodium channel subunit alpha MKGDKPEEPGPGPEPSGPPPPTEEEEALLEFHRSYRELFEFFCNNTTIHGAIRLVCSQHN RMKTVFWAVLWLCTFGMMYWQFGQLFGEYFSYPVSLNINLNSDKLVFPAVSICTLNPYRY KEIQEELEELDRITEQTLFDLYKYNSSKTLVAHARSRRDLREPLPHPLQRLPVPAPPHAA RGVRRAGSSMRDNNPQVNRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL SRRRQDTSPSLEEDVLGKFIFTCRFNQDSCNEANYSHFHHPMYGNCYTFNDKNSSNLWMS SMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHERDEPAFMDDAGFNLRPGVETSISM SKEAVDRLGGDYGDCTKNGSEVPVENLYNTKYTQQVCIHSCFQESMIKECGCAYIFYPRP DGVEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTIYKLSASYSQWPSATSQ DWVFQMLSRQNNYTIKNKRDGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWSLWF GSSVLSVVEMAELIIDLLVITFLMLLRRFRSRYWSPGRGGKGTQEVASTPAASLPSSFCP HPAFFSSSPPDPAISPALSAPPPAYATLGPHPAPSGLAEASTSAHAPGEP AAB48988.1 P55270 SCNNA_BOVIN U14944 SCNN1A