1.0 2018-05-07 22:30:22 UTC 2020-05-20 21:04:06 UTC BMDBP02175 Enzyme AQP4 Carbohydrate transport and metabolism Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. BMDB0002111 Water 24 >972 bp ATGAGTGACAGACCCGCAGCGAGGCGGTGGGGTAAGTGTGGACCTTTGTGTACAAGAGAG AGTATCATGGTGGCCTTCAAAGGGGTCTGGACACAAACTTTCTGGAAGGCAGTCACTGCG GAATTTCTGGCCATGCTTATTTTTGTCCTGCTCAGCCTGGGATCCACCATCAACTGGGGT GGAGCAGAAAAGCCACTACCTGTCGACATGGTTCTCATCTCCCTCTGCTTTGGACTCAGC ATCGCGACTATGGTCCAGTGCTTTGGCCACATCAGTGGTGGCCACATCAACCCCGCTGTG ACGGTGGCCATGGTGTGCACCAGGAGGATTAGCATCGCCAAGTCTGTCTTCTACATTGCA GCTCAGTGCCTGGGCGCCATCATTGGAGCCGGAATTCTCTACCTGGTCACGCCTCCCAGT GTGGTAGGGGGCCTTGGAGTCACCACGGTTCACGGAAATCTTAGCGCTGGACACGGTCTC CTGGTGGAGTTGATAATCACATTTCAGTTGGTGTTTACTATTTTTGCCAGCTGTGATTCC AAACGGACTGATGTCACCGGTTCCATAGCTTTAGCCATTGGGATCTCTGTTGCAATTGGA CATTTATTTGCAATCAATTACACTGGTGCCAGCATGAACCCCGCCCGATCCTTTGGACCT GCAGTTATCATGGGAAATTGGGAGAACCACTGGATATATTGGGTTGGACCAATCATAGGA GCTGTCCTTGCTGGTGGCCTCTATGAGTATGTCTTCTGTCCAGATGTTGAACTCAAACGT CGATTTAAAGAAGCCTTCAGCAAAGCTGCCCAGCAAACAAAAGGGAGCTACATGGAGGTG GAGGACAACAGGAGTCAGGTAGAGACCGACGACTTGATTCTAAAACCCGGAGTGGTGCAC GTGATCGACATTGACCGGGGGGAGGAGAAGAAAGGGAAAGACCCATCTGGAGAGGTGTTG TCTTCAGTATGA 323 34672.0 7.75 37-57 70-89 116-136 156-176 185-205 232-252 None >Aquaporin-4 MSDRPAARRWGKCGPLCTRESIMVAFKGVWTQTFWKAVTAEFLAMLIFVLLSLGSTINWG GAEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSVFYIA AQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDS KRTDVTGSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG AVLAGGLYEYVFCPDVELKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH VIDIDRGEEKKGKDPSGEVLSSV BAA36505.2 O77750 AQP4_BOVIN AB015947 AQP4