<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:30:24 UTC</creation_date>
  <update_date>2020-05-20 21:07:51 UTC</update_date>
  <accession>BMDBP02182</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>CCR5</gene_name>
  <general_function>Involved in G-protein coupled receptor protein signalin</general_function>
  <specific_function>Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000230</accession>
      <name>N-Acetylneuraminic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000464</accession>
      <name>Calcium</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>22</chromosome_location>
    <locus/>
    <gene_sequence/>
  </gene_properties>
  <protein_properties>
    <residue_number>352</residue_number>
    <molecular_weight>40235.0</molecular_weight>
    <theoretical_pi>9.39</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>31-58</region>
      <region>69-89</region>
      <region>103-124</region>
      <region>142-166</region>
      <region>199-218</region>
      <region>236-260</region>
      <region>278-301</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;C-C chemokine receptor type 5
MDYQTSTPLYDIDYGMSEPCQKLNVRQIAARLLPPLYSLVFIFGFVGNMLVVLILINCKK
LKSMTDIYLLNLAISDLLFIITIPFWAHYAADQWVFGNTMCQLFTGFYFIGYFGGIFFII
LLTIDRYLAIVHAVFALKARTVTFGAATSVVTWVVAVFASLPGIIFTKSQKEGSRHTCSP
HFPSSQYHFWKNFQTLKIVILGLVLPLLVMIVCYSGIIKTLLRCRNEKKKHKAVRLIFVI
MIVYFLFWAPYNIVLLLSTFQEFFGLNNCSGSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLRFFRKYFASRFCKGCPVFQGEAPERVSSVYTRSTGEQEISVGL</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAV97929.1</genbank_protein_id>
  <uniprot_id>Q2HJ17</uniprot_id>
  <uniprot_name>CCR5_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>AY834252</genbank_gene_id>
  <genecard_id>CCR5</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
