| Identification |
|---|
| BMDB Protein ID
| BMDBP02193 |
| Secondary Accession Numbers
| |
| Name
| Guanine nucleotide-binding protein G(s) subunit alpha isoforms short |
| Synonyms
|
Not Available
|
| Gene Name
| GNAS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:2022671, PubMed:9395396, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q22 |
| SNPs
| GNAS |
| Gene Sequence
|
>1185 bp
ATGGGCTGTCTCGGAAACAGCAAGACCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGC
GAGGCCAACAAGAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACG
CACCGTCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAAATG
AGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCA
AGGAGCAACAGCGATGGTGAGAAGGCCACCAAAGTGCAGGACATCAAAAACAACCTGAAA
GAGGCCATTGAAACCATCGTGGCCGCCATGAGCAACCTGGTGCCCCCTGTGGAGCTGGCC
AACCCAGAGAACCAGTTCAGAGTGGATTACATTCTGAGCGTGATGAACGTGCCGGACTTT
GATTTCCCTCCCGAATTCTACGAGCATGCCAAGGCTCTCTGGGAGGATGAAGGGGTGCGT
GCCTGCTATGAGCGCTCCAACGAGTACCAGCTGATTGACTGCGCCCAGTACTTCCTGGAC
AAGATTGATGTCATCAAGCAGGATGACTACGTGCCCAGCGACCAGGATCTGCTCCGCTGC
CGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCAC
ATGTTTGACGTGGGCGGCCAGCGCGATGAACGCCGCAAATGGATCCAATGCTTCAATGAT
GTGACTGCCATCATCTTCGTGGTTGCCAGCAGCAGCTACAACATGGTCATTCGGGAGGAC
AACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAATAACAGA
TGGCTGCGCACCATCTCTGTGATTCTGTTCCTCAACAAGCAAGATCTGCTGGCTGAGAAA
GTCCTTGCTGGAAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACT
CCTGAGGATGCGACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTC
ATTCGAGATGAATTTCTGAGAATCAGCACTGCTAGTGGAGACGGGCGCCACTACTGCTAC
CCTCACTTCACCTGCGCTGTGGACACCGAGAACATCCGCCGTGTGTTCAACGACTGCCGT
GACATCATCCAGCGCATGCACCTCCGTCAGTATGAGCTGCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 394 |
| Molecular Weight
| 45709.0 |
| Theoretical pI
| 5.4 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELA
NPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLD
KIDVIKQDDYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFND
VTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK
VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
|
| External Links |
|---|
| GenBank ID Protein
| CAA27137.1 |
| UniProtKB/Swiss-Prot ID
| P04896 |
| UniProtKB/Swiss-Prot Entry Name
| GNAS2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X03404 |
| GeneCard ID
| GNAS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
