| Identification |
|---|
| BMDB Protein ID
| BMDBP02198 |
| Secondary Accession Numbers
| None |
| Name
| Guanine nucleotide-binding protein-like 3-like protein |
| Synonyms
|
Not Available
|
| Gene Name
| GNL3L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| GNL3L |
| Gene Sequence
|
>1728 bp
ATGATGAAACTTAGACACAAAAATAAAAAGCCAGGTAAAGGTTCCAAAGGCTGCAAGAAG
CCTGCAAAGCAGAATGGGAAGAAAGCAGCCACCAAAGTGGCCTACTCTCCCCAGTTTTTC
CACTCCAATGATCACGCCAGTCGGGAGGCTGAGTTAAAGAAGAAGAGGGTTGGGGAAATG
AGGGAGAAGCAGCAGGCTGCCCGGGAGCAAGAGCGACACCGACGTAGGACCATTGAAAGC
TACTGCCAGGATGTCCTGAGACGCCAAGAGGAGTTTGAGCACAAGGAGGAAGTTTTGCAA
GAATTAAATATGTTTCCTCAACTGGATGATGAGGCTACAAGGAAGGCTTATTACAAGGAG
TTCCATAAGGTGGTGGAATACTCTGATGTGATTCTGGAAGTCCTGGATTCCAGGGACCCA
TTGGGCTGCCGCTGCTTCCAAATGGAGGAGACTGTCCTACGGGCAGAAGGGAACAAGAAG
CTGGTCCTGGTCTTGAACAAGATTGACCTGGTCCCTAAGGAGGTTGTGGAGAAGTGGCTA
GAATACCTTCGGAATGAGCTGCCAACTGTGGCTTTCAAGGCCAGTACCCAGCATCAGGTC
AAAAACCTGAATCGCTGCAGTGTGCCAGTGGATCAAGCCTCCGAGTCACTGCTGAAGAGC
AAAGCCTGCTTTGGAGCTGAAAACCTCATGAGGGTTCTGGGGAACTATTGCCGCCTTGGT
GAAGTGCGCACCCATATCCGAGTGGGCGTTGTGGGCCTTCCCAATGTTGGGAAGAGCAGC
CTGATCAATAGTCTGAAGCGCAGCCGTGCGTGTAGTGTGGGAGCCGTTCCTGGGGTCACC
AAGTTCATGCAGGAGGTCTACCTGGACAAGTTCATCAGGCTGCTGGATGCTCCGGGCATC
GTCCCAGGACCCAACTCAGAGGTGGGCACTATCCTGCGCAATTGCATTCACGTGCAGAAG
CTGGCGGACCCTGTGACCCCGGTGGAGACCATCCTGCAACGCTGCAACCTGGAGGAGATC
TCCAGCTATTATGGTGTCTCTGGGTTTCAGACCACTGAGCACTTTCTGACTGCAGTGGCC
CACCGCTTGGGGAAGAAGAAGAAGGGGGGCATTTATAGTCAGGAGCAGGCAGCCAAAGCT
GTGCTGGCTGACTGGGTGAGTGGGAAGATCAGCTTCTATACACTTCCACCCTCTACCCAC
ACTCTGCCTACCCATCTCAGTGCTGAGATCGTTAAGGAGATGACTGAGGTCTTTGACATT
GAGGATACCGAGCAAGCCAATGAAGACACCATGGAATGCTTGGCCACTGGAGAATCGGAT
GAGCTGTTGGGTGACATGGACCCGCTCGAAATGGAGATCAAGTGGCTCCATTCTCCGATG
GTGAAAATAGCAGATGCCATGGAAAATAAAACCACCGTGTATAAGATTGGAGATCTTACT
GGGTATTGCACCAATCCAAACCGTCATCAGATGGGATGGGCTAAGCGCAATGTGGACCTT
CACCCTAGGAACAATAGCATGGTGGATGTTTGCCCAGTGGACCGCCGCCCAGTGCTACAG
AGGATCATGGAGACAGACCCCCTGCAGCAGGGCCAGGCTCTGGCATCTGCCCTGAAGAAG
AAGAAGAAGATCCAGAAGCGTGCAGACAAACTTGCCAGCAAGCTGTCTGATTCCATGATG
TCCGCTCTTGACCTCTCTGGCAATGCTGATGACAGTGCTGGTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 575 |
| Molecular Weight
| 64837.0 |
| Theoretical pI
| 8.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Guanine nucleotide-binding protein-like 3-like protein
MMKLRHKNKKPGKGSKGCKKPAKQNGKKAATKVAYSPQFFHSNDHASREAELKKKRVGEM
REKQQAAREQERHRRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKE
FHKVVEYSDVILEVLDSRDPLGCRCFQMEETVLRAEGNKKLVLVLNKIDLVPKEVVEKWL
EYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLG
EVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGVTKFMQEVYLDKFIRLLDAPGI
VPGPNSEVGTILRNCIHVQKLADPVTPVETILQRCNLEEISSYYGVSGFQTTEHFLTAVA
HRLGKKKKGGIYSQEQAAKAVLADWVSGKISFYTLPPSTHTLPTHLSAEIVKEMTEVFDI
EDTEQANEDTMECLATGESDELLGDMDPLEMEIKWLHSPMVKIADAMENKTTVYKIGDLT
GYCTNPNRHQMGWAKRNVDLHPRNNSMVDVCPVDRRPVLQRIMETDPLQQGQALASALKK
KKKIQKRADKLASKLSDSMMSALDLSGNADDSAGD
|
| External Links |
|---|
| GenBank ID Protein
| AAI02364.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0J9 |
| UniProtKB/Swiss-Prot Entry Name
| GNL3L_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102363 |
| GeneCard ID
| GNL3L |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
