1.0 2018-05-07 22:30:47 UTC 2020-05-20 21:11:46 UTC BMDBP02264 Enzyme Involved in voltage-gated sodium channel activity Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. BMDB0000588 Sodium 22 >6069 bp ATGGCAGCCTTCCTGTTACCTCGGGGCACCAGCAGCTTCCGCAGGTTCACCCGGGAGTCT CTGGCGGCCATCGAGAAGCGCATGGCAGAGAAGCAGGCCCGGAGCTCGGCCGCCTCGCAG GAGAGCCGCGACGGGCTGCCCGAGGAGGAGGCGCCCCGGCCCCAGCTGGACCTGCAAGCC TCCAAAAAGCTGCCGGATCTCTACGGCAACCCACCCCGAGAGCTCATCGGGGAGCCCCTG GAGGACCTGGACCCCTTCTATAGCACTCAAAAGACCTTCATCGTCCTGAACAAAGGCAAG ACCATCTTCCGGTTCAGCGCCACCAACGCCTTGCATGTCCTCAGCCCCTTCCACCCCATC CGGAGAGTGGCTGTGAAGATCTTGGTGCATTCGCTCTTCAGCATGCTCATCATGTGTACC ATTCTGACCAACTGCGTGTTCATGGCCCAGCACGACCCTCCGCCCTGGACCAAATATGTC GAGTACATCTTCACTGCCATCTACACCTTTGAGTCTCTGGTCAAGATTCTGGCTCGAGGC TTCTGCCTGCACGCGTTCACCTTCCTTCGGGACCCGTGGAACTGGCTGGACTTCAGCGTG ATCATCATGGCATACACCACTGAATTTGTGGACCTGGGCAATGTCTCAGCTTTACGTACC TTCCGAGTCCTCCGGGCCCTGAAAACTATATCAGTCATTTCAGGCCTGAAGACCATCGTG GGGGCCCTGATCCAGTCTGTGAAGAAGCTGGCCGATGTGATGGTCCTCACGGTCTTCTGC CTCAGCGTCTTCGCCCTCATCGGCCTTCAGCTCTTCATGGGCAACCTGAGGCACAAGTGC GTCCGCAACTTCACGGTGCTCAACGGCACCAACAGCACCAATGCCTCCGTGGAGGCCGAC GGCCTGATCTGGGCATCGCTGGACGACTACCTCAACGACCCAGAAAATTACCTACTCAAG AATGGCACCTCTGACGTGTTACTGTGTGGGAACAGCTCCGACGCTGGGACATGTCCTGAG GGCTACAGGTGCCTGAAGGCAGGTGGGAACCCTGACCATGGCTACACCAGCTTCGACTCC TTCGCCTGGGCCTTCCTCGCACTCTTCCGACTGATGACGCAGGACTGCTGGGAGCGCCTC TACCAGCAGACCCTGAGGTCTGCAGGGAAGATCTACATGATCTTCTTCATGCTGGTCATC TTCCTGGGCTCCTTCTACTTGGTGAACTTGATCCTGGCTGTGGTCGCCATGGCCTACGAG GAGCAAAACCAAGCCACCATCGCAGAGACAGAGGAGAAGGAAAAGCGATTCCAGGAAGCC ATGGAGTTGCTCAAGAAAGAGCAGGAGGCCCTCGCCATCAGGGGTGTGGACACCGTGTCC CGCAGCTCCTTGGAGATGTCCCCATTGGCCCCAGTAACCACCCACGAGAGAAGGAGCAAG AGAAGAAAACGAATGTCTTCAGGGATGGAAGAGTGTGGGGACGACAAGTTCCCCAAGTCC GACTCAGAGGATGGTCCCCGAGCAGTGAATCGTTTCAGCATCACCCATGGCCTCAGCAGG ACCTCCATGAAGCCGCGCTCCAGCCACGGGAGCATTTTCACCTTCCGCCGACGGGACCTG GGCTCCGAGACAGATTTTGCGGACGATGAAAACAGCACCGCCGGGGACAGTGAGAGCCAC CGCACATCACTGCTGGTGCCTTGGCCCCTGCGGCGGCCTAGTACCCTGGGACAGCCCAGT CCCGGAACCTCAACTCCCGGCCACGTGCTCAACGGCAAAAGGAACAGCACTGTGGACTGT AACGGGGTGGTCTCCTTGCTGGGGGCAGGAGACCCCGAGGCCACCTCCCCAGGGAGTCAC CTCCTCCACCCTATGAAGCTGGAGCGCCCCCCAGACACGACCACACCATCGGAGGAGCCG GGCAGGCCCCAGACGCTGACGCCCCAGGCTCCGTGTGTAGACGGCTTCGAGGAGCCAGGA GAGCGGCAGCGAGCCCTCAGTGCAGTGAGCGTCCTCACCAGTGCCCTGGAAGAGCTGGAG GAGTCTCAGCGCAGGTGTCCACCGTGCTGGATCCGTTTTGCCCAGCACTACCTGATCTGG GAGTGCTGCCCGCTGTGGATGTCCATTAAGCAGAAAGTGAAGTTCATGGTCATGGACCCA TTTGCTGACCTCACCATCACCATGTGCATCGTGCTTAACACGCTCTTCATGGCACTGGAG CACTACAACATGACGACCGAATTTGAGGAGATGCTGCAGGTTGGAAACCTGGTCTTCACA GGAATATTCACAGCAGAGATGACCTTCAAGATCATTGCCTTGGACCCCTACTACTACTTC CAGCAGGGCTGGAACATCTTCGACAGCATCATCGTCATCCTCAGCCTCATGGAGCTGGGC CTGTCCCGCATGGGCAATCTGTCGGTGCTTCGCTCCTTCTGCCTGCTTCGGGTCTTCAAG CTGGCCAAGTCCTGGCCCACCCTGAACACACTCATCAAGATCATTGGGAACTCAGTGGGC GCGCTAGGCAACCTGACGTTGGTGCTGGCCATCATTGTGTTCATCTTCGCTGTGGTGGGC ATGCAGCTCTTTGGCAAGAACTACTCAGAGCAGAGGCACCGTATCAGTGACTCGGGCCTC CTGCCCCGCTGGCACATGATGGACTTCTTCCATGCCTTCCTCATCATCTTCCGCATCCTC TGTGGAGAGTGGATCGAGACCATGTGGGACTGCATGGAGGTGTCTGGGCAGTCACTATGC CTGCTGGTCTTCCTGCTTGTTATGGTCATTGGTAACCTCGTGGTCCTGAACCTCTTCCTG GCTTTACTGCTCAGCTCCTTCAGCGCAGACAACCTCACAGCTCCCGACGAGGATGGGGAG ATGAACAACCTCCAGCTGGCTCTGGCCCGCATCCAGCGAGGCCTGCGCTTCATCAAGCGG ACCACCTGGGACTTCTGCTGCGTGCTCCTGCAGCGGCCGCCTCAGAAGCCCGCGGCCCTC GCCTCCCAGGGCCAGCTGCCGGGCTGTATCGCCACCTCCAGCCCCCCACCCCAACCAGAG AGCGAGAAGGCGCCCCCAGCCCGCAAGGAGACGCGGTTTGAGGAAGGCCAGCGGCCAGGT CAGGGCGCACCTGGGGATGCCGAGCCTGTGTGTGTGCCCATCGCCGTGGCCGAGTCAGAC ACGGATGACCCCGAGGAGGATGAGGAGAACAGCCTAAGCACAGAGGAAGAGTCCAGCAAG CAGCAGGAATCCCAGCTGGCGTCCGGCAGCCCAGAGGCCCTCCCAGAGCCGAGGGTCTGG AGCCAGGTGTCGGAGACCACCTCCTCTGGGGCCGAGGCCAGTGAGGTTCAGGCAGACTTG CGGCAGCAGCGGCGAGCAGAGGCCCCCGCCCCAGGGTGCAGTGAGCTTCCCGAAGACAGT TACTCTGAGGGGAGCACGGCAGATATGACCAACACTGCTGACCTCCTGGAGCAGATCCCT GACCTCGGAGAGGATGTCAAAGATCCAGAGGACTGCTTCACTGAAGGCTGTGTCCGCCGC TGTCCCTGCTGCACCGTGGACACCACACAGGCCCACGGGAAGGTCTGGTGGAGGCTGCGC AAGACCTGCTACCGCATCGTGGAGCACAGCTGGTTCGAGACGTTCATCATCTTCATGATC CTGCTCAGCAGTGGCGCACTGGCCTTTGAGGACATCTACCTGGAGGAGCGGAAGACCATC AAGGTCCTGCTGGAGTACGCCGACAAGATGTTCACCTACGTCTTCGTGCTGGAGATGCTC CTCAAGTGGGTGGCCTACGGCTTCAAGAAGTACTTCACCAACGCCTGGTGCTGGCTTGAT TTCCTCATCGTGGACGTCTTGCTGATCAGCCTGGTGGCCAACGCCCTGGGCTTTGCTGAG ATGGGCCCCATCAAGTCACTGCGGACCTTGCGTGCGCTCAGACCCCTGCGAGCCCTGTCA CGATTTGAGGGCATGAGGGTTGTGGTTAACGCCCTGGTGGGCGCCATCCCATCCATCATG AACGTCCTCCTCGTCTGCCTCATCTTCTGGCTCATCTTCAGCATCATGGGCGTGAACCTC TTCGCGGGGAAGTTTGGGAGATGCATCAACCAGACCGAGGGAGACCTGCCCTTGAACTAT ACCATCGTGAACAACAAGAGCGACTGTGAGTCTTTCAATGTGACTGGCGAATTGTACTGG ACCAAGGTGAAGGTCAACTTTGACAACGTGGGGGCCGGGTACCTGGCCCTTCTGCAGGTG GCAACATTTAAAGGCTGGATGGACATCATGTATGCAGCTGTAGACTCCAGGGGGTACGAG GAGCAGCCCCAGTGGGAATACAACCTCTACATGTATATCTATTTTGTCATCTTCATCATC TTTGGGTCTTTCTTCACCCTGAACCTGTTCATCGGTGTCATCATTGACAACTTCAACCAG CAGAAGAAAAAGTTAGGGGGCCAGGACATCTTCATGACAGAGGAGCAGAAGAAGTACTAC AACGCCATGAAGAAGCTGGGCTCCAAGAAGCCCCAGAAGCCCATCCCACGGCCCCTGAAC AAGTACCAGGGCTTCATATTCGACATTGTGACCAAGCAGGCCTTCGACGTCACCATCATG TTTCTCATCTGCTTAAACATGGTGACCATGATGGTGGAGACAGACGACCAGAGCCCCGAG AAGGTCAACATCTTGGCCAAGATCAACCTGCTGTTCGTGGGCATCTTCACAGCCGAGTGT ATCTTCAAGATGGTTGCCCTGCGCCACTATTACTTCACCAACAGCTGGAACATCTTCGAC TTCGTGGTTGTCATCCTCTCCATCGTAGGCACTGTGCTCTCAGACATCATCCAGAAGTAC TTCTTCTCCCCGACGCTCTTCCGCGTCATCCGCCTGGCCCGCATCAGCCGCATCCTCAGG CTGATCCGCGGGGCCAAGGGCATCCGCACGCTTCTCTTCGCCCTCATGATGTCCCTGCCC GCGCTCTTCAACATCGGGCTGCTGCTCTTCCTCGTCATGTTCATCTACTCCATCTTCGGC ATGGCCAACTTCGCCTACGTCAAGTGGGAGGCTGGCATCGACGACATGTTCAACTTCCAG ACCTTCGCCAACAGCATGCTGTGCCTCTTCCAGATCACCACGTCGGCGGGCTGGGATGGG CTCCTCAGCCCCATCCTCAACACGGGGCCCCCCTACTGCGACCCCAACCTGCCCAACAGC AACGGCTCCCGGGGCAACTGCGGGAGCCCCGCGGTGGGCATCCTCTTCTTCACCACCTAC ATCATCATCTCCTTCCTCATTGTGGTCAACATGTACATCGCCATCATCCTGGAGAACTTC AGCGTGGCCACGGAGGAGAGCACGGAGCCCCTGAGTGAGGATGACTTCGACATGTTCTAC GAGATCTGGGAGAAGTTCGACCCGGAGGCCACCCAGTTCATCGAGTATTTGGCCCTGTCT GACTTCGCCGATGCCCTGTCAGAGCCACTCCGGATCCCCAAGCCCAACCAGATAAGCCTC ATCAATATGGACCTGCCCATGGTGAGTGGAGACCGCATCCACTGCATGGACATCCTCTTT GCCTTCACCAAGAGGGTCCTGGGCGAATCTGGGGAGATGGACGCCCTGAAGATCCAGATG GAGGAGAAGTTCATGGCGGCCAACCCGTCCAAGATCTCCTACGAGCCCATCACCACCACG CTGCGGCGGAAGCACGAGGAGGTGTCGGCCACGATCATCCAGCGGGCCTTCCGCCGGCAC CTGCTGCAGCGCTCCGTCAAGCACGCCTCCTTCCTCTACCGCCAGCAGGCGGGCAGCAGC GGCCTCTCGGAGGAGGACGCCCCCGAGCAGGAGGGCCTCATCGCCTACATGATGAACGAG AACTTCTCCCGCCGCCCCGGCCCGCCCTCCAGCTCCTCCGTCTCCTCCACGTCCTTCCCG CCCTCCTACGACAGCGTCACCAGGGCCACCAGCGACAACCCCCAGGTGCGGGCGTCTGAC TACAGCCCAAGCGAGGATCTCGCCGACTTCCCCCCAACCCCCGACAGGGACCGTGAGTCA ATCGTGTGA 2022 227894.0 5.23 127-147 159-178 230-247 253-273 391-419 721-739 751-772 784-801 841-864 884-901 921-944 1210-1229 1250-1266 1278-1299 1327-1353 1449-1475 1534-1552 1564-1586 1598-1614 1651-1679 1754-1777 None >Voltage-gated sodium channel alpha subunit MAAFLLPRGTSSFRRFTRESLAAIEKRMAEKQARSSAASQESRDGLPEEEAPRPQLDLQA SKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALHVLSPFHPI RRVAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYIFTAIYTFESLVKILARG FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTVLNGTNSTNASVEAD GLIWASLDDYLNDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGGNPDHGYTSFDS FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE EQNQATIAETEEKEKRFQEAMELLKKEQEALAIRGVDTVSRSSLEMSPLAPVTTHERRSK RRKRMSSGMEECGDDKFPKSDSEDGPRAVNRFSITHGLSRTSMKPRSSHGSIFTFRRRDL GSETDFADDENSTAGDSESHRTSLLVPWPLRRPSTLGQPSPGTSTPGHVLNGKRNSTVDC NGVVSLLGAGDPEATSPGSHLLHPMKLERPPDTTTPSEEPGRPQTLTPQAPCVDGFEEPG ERQRALSAVSVLTSALEELEESQRRCPPCWIRFAQHYLIWECCPLWMSIKQKVKFMVMDP FADLTITMCIVLNTLFMALEHYNMTTEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF QQGWNIFDSIIVILSLMELGLSRMGNLSVLRSFCLLRVFKLAKSWPTLNTLIKIIGNSVG ALGNLTLVLAIIVFIFAVVGMQLFGKNYSEQRHRISDSGLLPRWHMMDFFHAFLIIFRIL CGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGE MNNLQLALARIQRGLRFIKRTTWDFCCVLLQRPPQKPAALASQGQLPGCIATSSPPPQPE SEKAPPARKETRFEEGQRPGQGAPGDAEPVCVPIAVAESDTDDPEEDEENSLSTEEESSK QQESQLASGSPEALPEPRVWSQVSETTSSGAEASEVQADLRQQRRAEAPAPGCSELPEDS YSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCTVDTTQAHGKVWWRLR KTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEML LKWVAYGFKKYFTNAWCWLDFLIVDVLLISLVANALGFAEMGPIKSLRTLRALRPLRALS RFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNY TIVNNKSDCESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYE EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYY NAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE KVNILAKINLLFVGIFTAECIFKMVALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKY FFSPTLFRVIRLARISRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG MANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNS NGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFY EIWEKFDPEATQFIEYLALSDFADALSEPLRIPKPNQISLINMDLPMVSGDRIHCMDILF AFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATIIQRAFRRH LLQRSVKHASFLYRQQAGSSGLSEEDAPEQEGLIAYMMNENFSRRPGPPSSSSVSSTSFP PSYDSVTRATSDNPQVRASDYSPSEDLADFPPTPDRDRESIV CAC80974.1 Q8WMP8 Q8WMP8_BOVIN AJ251721