| Identification |
|---|
| BMDB Protein ID
| BMDBP02265 |
| Secondary Accession Numbers
| None |
| Name
| Sodium-driven chloride bicarbonate exchanger |
| Synonyms
|
Not Available
|
| Gene Name
| SLC4A10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in inorganic anion exchanger activity |
| Specific Function
| Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| SLC4A10 |
| Gene Sequence
|
>3354 bp
ATGCAGTCTGGAACCTGTGAGTCTTTTCAATCTCTAAGTCATCAGAGAAATGATGAAGAA
GCAGTTGTGGATAGAGGTGGAACTCGTTCTATTCTCAAAACACACTTTGAGAAAGAAGAT
TTAGAAGGTCATCGGACACTATTTATTGGCGTTCATGTGCCCCTGGGAGGAAGAAAAAGC
CATCGACGTCACAGGCATCGTGGTCATAAACACAGAAAGAGAGACAGAGAGAGAGATTCA
GGACTAGAGGATGGAAGGGAGTCACCTTCCTTTGACACCCCATCACAGCGAGTACAGTTT
ATTCTTGGGACTGAGGATGATGATGAGGAGCACATTCCTCATGACCTCTTCACAGAACTC
GATGAGATTTGCTGGCGTGAAGGTGAGGATGCTGAGTGGCGAGAAACAGCCAGGTGGTTG
AAGTTTGAAGAAGATGTGGAAGATGGAGGGGAAAGGTGGAGCAAGCCTTATGTGGCTACT
CTTTCACTGCACAGCTTATTTGAGTTAAGAAGTTGTATTCTGAATGGAACTGTGTTGCTG
GACATGCATGCCAATACTTTAGAAGAAATTGCAGATATGGTCCTTGACCAACAAGTGAGC
TCAGGTCAGCTCAATGAGGATGTACGCCACAGGGTCCACGAGGCTCTGATGAAACAGCAT
CACCACCAGAATCAGAAGAAGCTCACCAATAGGATTCCCATTGTTCGTTCCTTTGCTGAT
ATTGGCAAGAAACAATCAGAACCAAATTCCATGGATAAAAATGCAGGCCAGGTTGTTTCT
CCTCAGTCTGCACCAGCCTGTGTTGAAAATAAAAATGATGTGAGCAGGGAAAACAGCACA
GTTGATTTCAGCAAGGGGCTGGGAGGCCAACAAAAGGGGCATACTAGCCCATGTGGGATG
AAACAAAGACATGAGAAAGGACCTCCACACCAGCAAGACAGAGAGGTCGATCTGCATTTT
ATGAAGAAGATTCCTCCAGGTGCTGAAGCCTCCAACATCTTAGTTGGAGAATTAGAGTTT
TTGGATCGAACTGTAGTTGCATTTGTCAGGCTGTCCCCAGCTGTACTGCTTCAAGGATTA
GCTGAGGTCCCAATCCCAACCAGATTTTTGTTCATTCTTCTGGGACCCCTGGGAAAGGGT
CAACAGTACCATGAGATTGGCAGATCAATTGCAACCCTAATGACAGATGAGGTGTTTCAT
GATGTTGCTTACAAAGCAAAAGATCGTAATGACTTGGTGTCAGGAATTGACGAATTTCTG
GATCAGGTGACTGTCCTTCCTCCCGGAGAGTGGGACCCAAGCATTCGAATAGAGCCTCCC
AAAAATGTTCCTTCCCAGGAGAAGAGGAAGATTCCTGCTGTACCAAATGGAACAGCAGCT
CATGGGGAAGCTGAGCCCCATGGAGGACATAGTGGACCTGAACTCCAGCGAACTGGAAGG
CTTTTTGGGGGACTTATTTTAGATATCAAAAGAAAAGCTCCATACTTCTGGAGTGACTTC
ACAGATGCTCTCAGCCTGCAGTGTTTAGCGTCTTTTCTGTTTCTCTACTGCGCATGTATG
TCTCCTGTCATCACATTTGGAGGACTGCTGGGAGAAGCAACTGAGGGTCGAATAAGTGCA
ATCGAGTCTCTCTTTGGAGCATCCATGACTGGAATAGCCTATTCTCTTTTTGGTGGACAG
CCTCTTACCATACTAGGCAGTACAGGACCAGTTTTGGTGTTTGAAAAGATTTTGTTTAAA
TTTTGCAAAGAATATGGGCTATCATACCTGTCTTTAAGAGCTAGTATTGGACTTTGGACT
GCAACCCTGTGTATCATACTTGTGGCCACTGATGCAAGCTCCCTTGTCTGCTATATCACC
CGGTTTACTGAAGAAGCTTTTGCTTCTCTTATTTGCATCATTTTCATTTATGAGGCCCTA
GAGAAGTTGTTTGAACTCAGCGAAGCATATCCAATCAACATGCATAATGATTTGGAACTG
CTGACACAGTACTCATGTAACTGTGTGGAGCCACATAATCCTAGTAATAATACATTGAAG
GAATGGAGGGAGTCCAATATTTCTGCCTCTGACATAATTTGGGAGAACCTAACTGTTTCG
GAATGCACATCACTGCACGGGGAGTATGTTGGACGAGCCTGCGGCCACGAGCACCCCTAT
GTTCCAGATGTTCTGTTTTGGTCAGTGATCCTCTTCTTTTCCACAGTTACTCTGTCAGCC
ACGTTGAAGCAGTTCAAGACTAGCCGCTATTTTCCAACCAAGGTTCGATCCATAGTGAGT
GACTTTGCTGTCTTTCTTACGATTCTATGTATGGTTTTAATTGACTATGCCATTGGGATC
CCGTCTCCAAAACTACAAGTACCAAGTGTTTTCAAGCCCACAAGAGATGATCGTGGCTGG
TTTGTTACACCTTTAGGTCCAAATCCATGGTGGACAGTAATAGCTGCTATTATTCCAGCT
TTACTTTGTACTATTCTAATTTTTATGGACCAACAGATTACAGCTGTCATTATCAACAGA
AAAGAACATAAGCTAAAGAAAGGTTGTGGGTACCATCTGGATCTGTTAATGGTGGCTGTC
ATGCTGGGTGTGTGCTCCATCATGGGCCTGCCATGGTTTGTGGCTGCCACTGTCCTTTCC
ATCACTCATGTCAACAGCCTGAAACTGGAATCTGAATGTTCAGCTCCAGGAGAACAACCC
AAATTTCTTGGCATTCGGGAGCAAAGAGTTACTGGGCTTATGATTTTCATTCTCATGGGC
TCATCAGTCTTTATGACTAGTATTCTGAAGTTTATTCCTATGCCAGTGCTATATGGAGTG
TTTCTTTATATGGGTGCTTCGTCACTAAAAGGAATTCAGTTCTTTGATAGAATAAAGCTC
TTCTGGATGCCTGCAAAACATCAACCAGATTTTATATATCTAAGGCATGTGCCACTTCGA
AAAGTCCATCTCTTCACAGTTATTCAGATGAGTTGCCTCGGCCTTTTGTGGATAATAAAA
GTTTCACGAGCTGCTATTGTCTTTCCCATGATGGTGTTAGCTCTGGTATTTGTAAGAAAA
TTGATGGACTTTTTGTTTACCAAACGGGAACTCAGCTGGTTGGATGATTTAATGCCTGAG
AGTAAGAAAAAGAAACTAGAAGATGCTGAAAAAGAAGAAGAACAAAGTATGCTAGCTATG
GAAGATGAAGGCACAGTACAGCTCCCACTGGAAGGGCACTATAGAGATGATCCATCTGTG
ATCAATATTTCTGATGAAATGTCAAAGACTGCCTTGTGGAGGAACCTTCTGATTACTGCC
GATAACTCAAAAGATAAGGAGTCAAGCTTTCCTTCTAAAAGCTCCCCTTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1117 |
| Molecular Weight
| 125776.0 |
| Theoretical pI
| 6.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 509-529
- 538-558
- 562-582
- 596-616
- 626-646
- 720-740
- 762-782
- 809-829
- 855-875
- 912-932
- 935-955
- 998-1018
|
| Protein Sequence
|
>Sodium-driven chloride bicarbonate exchanger
MQSGTCESFQSLSHQRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKS
HRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIPHDLFTEL
DEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLL
DMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFAD
IGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENSTVDFSKGLGGQQKGHTSPCGM
KQRHEKGPPHQQDREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGL
AEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFL
DQVTVLPPGEWDPSIRIEPPKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPELQRTGR
LFGGLILDIKRKAPYFWSDFTDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISA
IESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWT
ATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLEL
LTQYSCNCVEPHNPSNNTLKEWRESNISASDIIWENLTVSECTSLHGEYVGRACGHEHPY
VPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGI
PSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINR
KEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQP
KFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKL
FWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRK
LMDFLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSV
INISDEMSKTALWRNLLITADNSKDKESSFPSKSSPS
|
| External Links |
|---|
| GenBank ID Protein
| AAI09484.1 |
| UniProtKB/Swiss-Prot ID
| Q32LP4 |
| UniProtKB/Swiss-Prot Entry Name
| S4A10_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109483 |
| GeneCard ID
| SLC4A10 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
