1.0 2018-05-07 22:30:50 UTC 2020-05-20 21:03:00 UTC BMDBP02275 Enzyme SLC5A12 Amino acid transport and metabolism Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). Thyroid Hormone Synthesis SMP0087269 BMDB0000588 Sodium 15 >1854 bp ATGGAGGTGAAGAACTTTGCAGTTTGGGATTATGTTGTCTTTGCAGCCCTCTTCATCATT TCCTCTGGAATTGGGGTGTTCTATGCGATTAAGGAGAGAAAAAAAGCAACTTCGAGGGAG TTTCTGGTCGGTGGCCGGCAAATGAGCTTTGGCCCAGTGGCATTATCCCTGACAGCCAGC TTCATGTCCGCCGTCACTGTCCTGGGGACCCCTGCCGACGTCTACCGCTTTGGAGCATCC TTCGTCCTCTTCTTCATCACGTACGGGTTAGTCATTATCCTCACGTCAGAGCTCTTTCTT CCTGTGTTCTACAGATCTGGCATCACCAGCACGTACGAGTACTTACAACTACGATTCAAC AAACCAGTTCGCTATGCAGCCACAGTCATCTACATCGTGCAAACGATTCTCTACACGGGA GTGGTGGTGTACGCTCCTGCTCTGGCCCTCAATCAAGTGACTGGGTTTGATCTCTGGGGC TCTGTGTTTGCAACGGGAATCGTTTGCACATTCTACTGTACCCTGGGAGGATTAAAAGCA GTAGTGTGGACAGATGCATTTCAGATGGTTGTCATGATCGTGGGCTTCTTAACGGTTCTC ATTCAAGGATCAACCTATGCTGGTGGATTACACAATGTATTAGAACAAGCAGAAAATGGA TCTCGATTAAATATATTTGACTTTGATATAGATCCTCTCAGGAGGCACACTTTTTGGACA ATCTCAGTGGGAGGAACCTTTACGTGGCTTGGGATCTATGGAGTTAATCAGTCGACCATC CAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCCAAGCTAGCCTTGTACTTCAACTTG CTAGGTCTCTGGATCATTCTGCTATGTGCAGTCTTTTCTGGTTTAACCATGTACGCGCAC TTCAAAGACTGTGATCCTTGGACTTCGGGCATCATCTCAGCCCCAGACCAGCTGATGCCA TACTTCGTCATGGAGTTATTTTCCACGATGCCTGGACTTCCAGGACTTTTCGTGGCTTGT GCCTTCAGTGGAACTTTGAGCACCGTGGCTGCCAGCATCAATGCCTTAGCAACAGTGACC TTTGAGGATTTTGTCAAGAGCTGTTTTCCTCGTCTCTCTGACAAGCTGAGCACCTGGATC AGTAAAGGCTTATGTCTTTTATTTGGCGTGATATGTACCTCCACAGCTGTGGCTGCATCC CTCATGGGTGGTGTCATACAGGCTGCCCTCAGTATCCACGGCATGTGTGGGGGGCCGATG CTGGGCTTGTTCTCTCTGGGAATTCTGTTCCCTTTTGTGAACTGGAAGGGTGCCCTAGCA GGCCTTCTGACCGGAATCCTCTTGTCATTTTGGGTGGCCATCGGGGCCTTCATTTACCCT GCACCAGCCTCTAAGACGTGGCCTTTGCCTTTGTCGACTGACCAGTGTGGCCTATCAAAC GTGACGGAATCGGTGCCTCCGGTGCTGTCCAGCAGACCCGCCATCGCTGAGACCTGGTAT GCCCTCTCCTACCTGCACTACAGCACCGTGGGCTGCCTGGGATGCATAGCTGCTGGAGTA ATCATCAGCTTCCTAACAGGTCTCCAAAAGGGCAAGGATATTCCACCACTGCTAATTAGA CCAGTCTGCAATTTATTTTGCTTTTGGTCTAAGAAATACAAAACACTGTGCTGGTGTGGA GTTCAGCATGACAGTGGAACAGAGCAGGAAAACCTTGAGAATGACAGTACCTGGAAACAA GGAGCTGAATCTGTCTTACAAAACGGCCTCAAGCAAGAAAGCCTGGTTCCAGGCTACGAT CCCAAGGACAAAAGCTATGACAACATGGCTTTAGAGAAGATTACCCATTTCTAA 617 67410.0 7.67 6-26 48-68 81-101 129-149 158-178 181-201 236-256 274-294 335-357 386-406 412-432 438-458 508-528 None >Sodium-coupled monocarboxylate transporter 2 MEVKNFAVWDYVVFAALFIISSGIGVFYAIKERKKATSREFLVGGRQMSFGPVALSLTAS FMSAVTVLGTPADVYRFGASFVLFFITYGLVIILTSELFLPVFYRSGITSTYEYLQLRFN KPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKA VVWTDAFQMVVMIVGFLTVLIQGSTYAGGLHNVLEQAENGSRLNIFDFDIDPLRRHTFWT ISVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILLCAVFSGLTMYAH FKDCDPWTSGIISAPDQLMPYFVMELFSTMPGLPGLFVACAFSGTLSTVAASINALATVT FEDFVKSCFPRLSDKLSTWISKGLCLLFGVICTSTAVAASLMGGVIQAALSIHGMCGGPM LGLFSLGILFPFVNWKGALAGLLTGILLSFWVAIGAFIYPAPASKTWPLPLSTDQCGLSN VTESVPPVLSSRPAIAETWYALSYLHYSTVGCLGCIAAGVIISFLTGLQKGKDIPPLLIR PVCNLFCFWSKKYKTLCWCGVQHDSGTEQENLENDSTWKQGAESVLQNGLKQESLVPGYD PKDKSYDNMALEKITHF AAI51503.1 A7MBD8 SC5AC_BOVIN BC151502 SLC5A12