1.0 2018-05-07 22:31:02 UTC 2020-05-20 21:08:50 UTC BMDBP02320 Enzyme BMI1 Involved in protein binding Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. BMDB0001303 Zinc 13 >981 bp ATGCATCGAACAACCAGAATCAAGATCACTGAGCTAAATCCCCACCTAATGTGTGTTCTT TGTGGAGGGTACTTCATTGATGCCACAACCATAATAGAATGTCTACATTCCTTCTGTAAA ACGTGTATTGTGCGTTACCTGGAGACCAGCAAGTATTGTCCTATCTGTGATGTCCAAGTT CACAAAACCAGACCACTACTGAATATAAGGTCAGATAAAACTCTTCAAGATATTGTATAC AAATTAGTTCCAGGGCTTTTCAAAAATGAAATGAAGAGAAGAAGGGATTTTTATGCCGCT CATCCTTCAGCTGATGCTGCCAATGGCTCTAATGAAGACAGAGGAGAAGTGGCTGATGAA GATAAGAGAATTATAACTGATGATGAGATAATAAGTTTATCCATTGAATTCTTTGACCAG AACAGATTGGATCGGAAAATAAACAAGGACAAAGAGAAATCTAAGGAGGAGGTGAATGAT AAAAGATATTTACGATGCCCAGCAGCAATGACTGTAATGCACCTAAGAAAGTTTCTCAGA AGTAAAATGGACATACCTAATACTTTCCAGATTGATGTCATGTATGAAGAGGAACCTTTA AAAGATTACTATACACTAATGGATATTGCCTACATTTATACCTGGAGAAGGAATGGCCCA CTTCCTTTGAAATACAGAGTTCGACCTACTTGTAAAAGAATGAAGATCAGTCATCAGAGA GATGGACTGACTAACACTGGAGAACTGGAAAGTGACTCTGGGAGTGACAAGGCCAACAGC CCAGCAGGAGGCATCCCCTCCACCTCTTCCTGTTTGCCCAGTCCCAGCACTCCAGTCCAG TCTCCTCATCCTCAGTTTCCTCACATTTCCAGTACTATGAATGGAACCAGCAGCAGCCCC AGCGGTAACCACCAATCTTCCTTTGCCAATAGACCTCGAAAATCATCAGTAAATGGGTCG TCAGCAACTTCATCTGGTTGA 326 36966.0 8.8 None >Polycomb complex protein BMI-1 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQV HKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADE DKRIITDDEIISLSIEFFDQNRLDRKINKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLR SKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQR DGLTNTGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSSSP SGNHQSSFANRPRKSSVNGSSATSSG AAI09872.1 Q32KX7 BMI1_BOVIN BC109871 BMI1