| Identification |
|---|
| BMDB Protein ID
| BMDBP02351 |
| Secondary Accession Numbers
| None |
| Name
| Tripartite motif-containing protein 2 |
| Synonyms
|
Not Available
|
| Gene Name
| TRIM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| TRIM2 |
| Gene Sequence
|
>2235 bp
ATGGCCAGTGAAGCCACCAACATCCCCAGTCCTGTGGTGCGCCAGATTGACAAGCAGTTT
CTGATTTGCAGTATATGCCTGGAAAGGTACAAGAATCCCAAGGTTCTCCCCTGTCTGCAC
ACTTTCTGCGAGAGGTGCCTGCAGAACTACATTCCCGCCCACAGCTTAACCCTCTCCTGC
CCGGTGTGCCGCCAGACCTCCATCCTGCCCGAGAAGGGGGTGGCCGCGCTCCAGAACAAC
TTCTTCATCACAAACCTGATGGATGTGCTGCAGCGATCTCCAGGCAGCAGCGCTGAGGAG
TCCTCCATTCTGGAGACCGTCACCGCCGTGGCTGCAGGGAAGCCTCTGTCATGCCCAAAC
CACGATGGGAATGTGATGGACTTCTACTGCCAGTCCTGTGAGACCGCCATGTGTCGGGAG
TGCACAGAGGGGGAGCACGCAGAGCACCCCACCGTCCCCCTCAAGGACGTGGTGGAGCAG
CACAAGGCTTCGCTCCAGGTGCAGCTGGACGCCGCCAACAGAAGGCTCCCAGAAATAGAT
TCAGCTCTTCAGTTCATCTCGGAAATCATCCATCAGTTAACCAACCAGAAGGCCAGTATT
GTGGACGACATCCATTCTACCTTTGATGAACTCCAGAAGACTTTAAACGTGCGCAAGAGT
GTGCTGCTCATGGAGCTGGAAGTCAACTATGGCCTCAAACACAAAGTCCTCCAGTCACAG
CTGGACACCCTGCTCGAGGGGCAGGAGAGCATCAAGAGCTGCAGCAACTTCACGGCACAG
GCCCTGAACCACGGCACGGAGACGGAGGTGCTGCTGGTGAAGAAGCAAATGAGCGAGAAG
CTCAATGAACTGGCGGACCAAGATTTCCCGCTGCACCCGCGAGAAAACGACCAACTGGAC
TTCATCGTGGAGACCGAGGGGCTCAAGAAGTCCATCCACAACCTCGGGACGATTCTGACC
ACCAATGCCGTCGCCTCCGAGACGGTGGCGACGGGCGAGGGGCTGCGGCAGACCATCATC
GGGCAGCCCATGTCTGTTACCATAACAACCAAGGACAAAGACGGCGAGCTGTGCAAAACG
GGCAACGCCTACCTCACGGCGGAGCTGAGCACGCCCGACGGCAGCGTGGCCGATGGGGAG
ATCCTGGACAACAAGAACGGCACGTACGAGTTCCTGTACACCGTGCAGAAGGAGGGCGAC
TTCACGCTGTCGCTGCGGCTCTACGACCAGCACATCCGCGGCAGCCCGTTCAAGCTGAAG
GTGATCCGCTCGGCGGATGTGTCCCCCACCACCGAGGGCGTGAAGCGGCGAGTGAAGTCC
CCTGGCAGCGGCCATGTGAAGCAGAAGGCTGTCAAGAGGCCCGCCAGCATGTACAGCACC
GGGAAGCGAAAAGAGAACCCCATCGAAGACGACCTGATCTTCCGAGTGGGTACCAAAGGA
AGAAATAAAGGGGAATTCACAAATCTTCAAGGGGTAGCGGCATCTACAAATGGAAAGATA
CTGATTGCTGACAGTAACAACCAGTGTGTGCAGATATTTTCCAATGATGGACAGTTCAAA
AGTCGTTTTGGCATACGAGGACGCTCTCCTGGGCAGCTGCAGCGTCCCACAGGAGTAGCC
GTGCATCCCAGTGGGGACATAATCATTGCTGATTATGATAACAAATGGGTTAGCATCTTC
TCATCAGATGGCAAGTTTAAGACAAAAATCGGATCAGGAAAGTTGATGGGGCCCAAAGGA
GTGTCTGTGGACCGCAATGGGCACATCATCGTGGTGGATAACAAGGCGTGCTGCGTCTTC
ATCTTCCAGCCGAATGGGAAAATAGTCACCAGGTTTGGTAGCCGAGGCAATGGGGACAGG
CAGTTTGCAGGTCCGCATTTCGCAGCTGTAAATAGCAATAATGAGATTATTGTTACAGAT
TTCCATAATCATTCTGTCAAGGTGTTTAATCAGGAAGGCGAATTCATGTTGAAGTTTGGC
TCAAATGGAGAAGGAAACGGGCAGTTTAATGCTCCCACGGGCGTAGCAGTGGATTCAAAT
GGAAACATCATCGTAGCCGACTGGGGGAACAGCAGGATCCAGGTGTTTGATGGAAGTGGG
TCGTTTTTGTCCTACATTAACACGTCTGCTGATCCACTCTATGGCCCCCAGGGCCTGGCC
CTAACTTCAGACGGCCACGTGGTGGTTGCAGACTCTGGAAACCACTGTTTCAAGGTCTAC
CGGTACTTACAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 744 |
| Molecular Weight
| 81476.0 |
| Theoretical pI
| 6.87 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>TRIM2 protein
MASEATNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSC
PVCRQTSILPEKGVAALQNNFFITNLMDVLQRSPGSSAEESSILETVTAVAAGKPLSCPN
HDGNVMDFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAANRRLPEID
SALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQ
LDTLLEGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLD
FIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKT
GNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLK
VIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKG
RNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVA
VHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVF
IFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIVTDFHNHSVKVFNQEGEFMLKFG
SNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLA
LTSDGHVVVADSGNHCFKVYRYLQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI34424.1 |
| UniProtKB/Swiss-Prot ID
| A4IF63 |
| UniProtKB/Swiss-Prot Entry Name
| TRIM2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC134423 |
| GeneCard ID
| TRIM2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
