1.0 2018-05-07 22:31:59 UTC 2020-05-20 21:01:19 UTC BMDBP02526 Enzyme SPRTN Involved in DNA binding Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity). BMDB0001303 Zinc 28 >1464 bp ATGGATGAGGACCTGGTTTTGGCACTACAGCTTCAGGAGGAGTGGAACTTGCAGGTCTCG GAGCGCGAACCGGCCCAGGAGCCCCTGTCTCTGGTGGACGCGTCTTGGGAGTTGGTGGAC CCTACCCCTGACTTACAGGGCCTGTTTGTTCTGTTCAACGACCGTTTCTTCTGGGGCCAA CTGGAGGCGGTCGAGGTGAAGTGGAGCGTGCGGATGACGCTGTGTGCTGGGATATGCAGC TATGAAGGGAGGGGTGGAATGTGTTCCATCCGTCTCAGTGAACCCCTTTTAAAGCTGAGA CCAAGAAAAGATCTTGTGGAGACCCTCTTGCATGAAATGATACATGCCTATTTATTTGTC ACTAATAATGATAAAGATCGGGAAGGGCATGGTCCAGAGTTTTGTAAGCATATGCATCGC ATCAATCGCCTGACAGGAGCCAATATAACGGTGTACCATACTTTCCATGACGAGGTAGAC GAGTACCGTCGACACTGGTGGCGCTGCAACGGGCCGTGTCAGAACAGTAAGCCGTATTAC GGCTATGTGAAGCGTGCCACCAACAGGGCACCCTCCGCCCATGACTACTGGTGGGCTGAA CACCAGAAAACCTGTGGAGGCACTTACATCAAAATCAAGGAACCAGAGAACTACTCAAAA AAGGGCAAAGGAAAGACAAAACTGAGAAAGCAGCCAGTATCAGAAGCAGAGAATAAAGAC AAACCGAACAGAGGGGAGAAACAGCTGTTAATCCCCTTTACCGGGAAAGGTTATGTCCTA GGGGAAACCAGCAATTTTTCATCTGGGAAATGTATCACTTCACATGCTATTAATGAAAGC CAAGAGCCTTTAAGTCAAGACCATTCAGCAAATGCCCTGAGACCTCATTCTAAAACTGAG GTGAAATTTGAACAGAATGGTCCAAGTAAAAAGACTTCTGTAGCATCCCCTGTTCTCAGT ACCAGTCATCAGAATGTCTTAAGCAACTACTTCTCTAAAGTGTCCGTTGCCAGCAGCAAG GCTTTCAGAAGTGTGAGTGGGTCTCCAGTGAAGAGCCTCACAGTGGGCGACAGCACTACA AAGTCGGTCTCTGCCGGTTCTCAAAGGAGGGTTACATCTTCTAGGACATCTCTAAGAAAT TCCTTAAAAGCCATGGAATCGACATATGTCACTGTGCCCCAGGATGCAGGTGGGCCTGAA GGTAAACTCCCAAGTAAACGACCCAGGATAGAAGACAAGACTTTTTTTGACCTCTTTTTT ATCAAGAAGGAGCAAGCGCAGAGTGGTGGTGGTGATGTGACGAGTAGTTCGCATCCTCCA GCTGCAGCGCAGAGTCCCAGCGGTGCATCCGGTCAGAGCAGGGTGGTGCACTGTCCCGTG TGTCAGGACGAGGTTTCGGAGACACAGATTAATGAGCACTTGGACTGGTGCCTTGAACGT GATAGCACCCAAGTCAAAAGCTGA 487 54521.0 8.35 None >Zinc finger RAD18 domain-containing protein C1orf124 homolog MDEDLVLALQLQEEWNLQVSEREPAQEPLSLVDASWELVDPTPDLQGLFVLFNDRFFWGQ LEAVEVKWSVRMTLCAGICSYEGRGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV TNNDKDREGHGPEFCKHMHRINRLTGANITVYHTFHDEVDEYRRHWWRCNGPCQNSKPYY GYVKRATNRAPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKTKLRKQPVSEAENKD KPNRGEKQLLIPFTGKGYVLGETSNFSSGKCITSHAINESQEPLSQDHSANALRPHSKTE VKFEQNGPSKKTSVASPVLSTSHQNVLSNYFSKVSVASSKAFRSVSGSPVKSLTVGDSTT KSVSAGSQRRVTSSRTSLRNSLKAMESTYVTVPQDAGGPEGKLPSKRPRIEDKTFFDLFF IKKEQAQSGGGDVTSSSHPPAAAQSPSGASGQSRVVHCPVCQDEVSETQINEHLDWCLER DSTQVKS ABQ12938.1 A5D979 SPRTN_BOVIN BT030498 SPRTN