<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:32:08 UTC</creation_date>
  <update_date>2020-05-20 21:07:09 UTC</update_date>
  <accession>BMDBP02558</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>POLR2M</gene_name>
  <general_function>Involved in DNA-directed RNA polymerase activity</general_function>
  <specific_function>Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0003339</accession>
      <name>D-Glutamic acid</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>10</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1002 bp
ATGTCCTCGCTGCCCCGCGGCTTCGAGCCCCAAACTCCCGAGGACTTGGGGCAGCGGAGT
TTGGCGGAGCTACGGGAAATGTTGAAGCGCCAGGAGAGACTTTTGCGCAACGTAAAATTC
ATTTGCAAATTGCCCGACAAAGGTAAAAAGATCTCAGACGCTGTCACCAAACTGAAAGCT
GCCATCGCAGAACGTGAAGAAGTTAGAGGAAGAAGTGAACTCTTTTATCCTGTTAGCTTA
GACTGTAAGGAGAGGCAAAAAGCGATTGCAGTTGTTGATGGGGACCGAGATAAGGCCCAG
AATTCTGACCAGATACTTGACACTTCATCACCCGTTCCTGGCTGTTCCTCTGTAGCTAAC
ATCACATCATCTCAGACAACCTCACGACAACAGGGACTGGCACATCCAACTCGAGGAGGT
GATGCTGAGGCAGCTGAGGCTGAACACACAGTGAGCGAGCACCCAACTTCTAGCAGCGGA
GCCCCAGCGCCTTCCTCATCTCAAGCTAGTGAGGGTCTCCCTCAGCATTGTGCCTTAGGT
CAAGTGGAGGATCATCCTGGCAGCTCAGACAACCTGTTCATTGATAGATTACAAAGGATC
ACAATTGCGGATCCGACTGAACACCACTCAGAAGGAAACCGGAATCCTGAGAACTTGGCC
GGCCTCTGGAGTGGGCCGCAGAAGAAGCCTCATTACATGGAAGTGCTGGAAATGCGAGCC
AAAAATCCCATGCCCCCGCCACATAAATTTAAAACCAATGTATTACCTTCACAGCCCCGT
GATTCATCGAGTGCTTGTCAGAGGAGAGGGTCTCCCATCTCCTCAGAGGAGAGGCGGCGC
AGGGACAGGAAGCATCTTGATGATATCACAGCGGCCCGGCTTCTGCCGCTGCACCACCTG
CCAACCCAGCTGCTCTCCATAGAGGAGTCGCTGGCACTTCAGAGACAGCAGAAGCAGAGT
TATGAGGAGATAAGCCAAGCTCGCAGCACAGAAGCTAGCTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>370</residue_number>
    <molecular_weight>41312.0</molecular_weight>
    <theoretical_pi>6.8</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Protein GRINL1A
MSSLPRGFEPQTPEDLGQRSLAELREMLKRQERLLRNVKFICKLPDKGKKISDAVTKLKA
AIAEREEVRGRSELFYPVSLDCKERQKAIAVVDGDRDKAQNSDQILDTSSPVPGCSSVAN
ITSSQTTSRQQGLAHPTRGGDAEAAEAEHTVSEHPTSSSGAPAPSSSQASEGLPQHCALG
QVEDHPGSSDNLFIDRLQRITIADPTEHHSEGNRNPENLAGLWSGPQKKPHYMEVLEMRA
KNPMPPPHKFKTNVLPSQPRDSSSACQRRGSPISSEERRRRDRKHLDDITAARLLPLHHL
PTQLLSIEESLALQRQQKQSYEEIQAKLAAQKLAERLNIKMQSYNPEGESSRKYREVRDE
DDDQSSEDEF</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI18413.1</genbank_protein_id>
  <uniprot_id>Q17QE3</uniprot_id>
  <uniprot_name>GRL1A_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC118412</genbank_gene_id>
  <genecard_id>POLR2M</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
