| Identification |
|---|
| BMDB Protein ID
| BMDBP02571 |
| Secondary Accession Numbers
| None |
| Name
| Chromatin assembly factor 1 subunit A |
| Synonyms
|
Not Available
|
| Gene Name
| CHAF1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. |
| Pathways
|
- BTG Family Proteins and Cell Cycle Regulation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| CHAF1A |
| Gene Sequence
|
>2895 bp
ATGCTGGAGGAGCCGGAGTGCGGGGCGCCGGGCGCCCGGGGAGAGGCCGCAGCCATGGAT
TGCAAAGACAGGCCAGCTTTTCCAGTCAAGAAGTTAATACAAGCCCGACTGCCATTCAAG
CGCCTGAATCTTGTCCCCAAGGAGAAAATTGACGATGGCTTGGACGACACAGGGGGGTCT
CGGGCTGGCCCTGTGCAGACTCAACTCCACAACTTAGAAACCTCTTTGGACCACTTGGAG
AACTGTCACATGGGTTCCGACATAGATTTTAGACCAAAACTTGTCAATGGGAAGGGACCC
TTAGATAACTTTTTAAGAAGTCAAGTTGAAACCAGTATTGGCCAGGCTGTGGTCATAATC
GATTTGACAGAGGACTCGAGCAACCCCCCGGACAACATGGTGGGCCACAATAAACTGAAT
TCTGCCGCCTCCTCCGCTCAGAAGAACATAAATGGAGTCCCAGACAAAGCTGGAGATGAC
AGGGGGCTGCCAAAGGCCAGGCAGAAGGATGAGCTGGCAAGTCCCGAAGAGGCCCTTTCA
GAAGTTCCGTGCAAGACAGAGGCAGGGGGTGCTGACTCGGGGGGTGCAGACAGGAGGGGA
CTCACACAGAGGGGCTCACCCCAAAACTGTCCCAAGCTGACTGGTGACCTGAGCATGTGG
TCTGAGAAGGACCGGGATGGCTGGAGTGAAGCCGGGGGCATCCTGTTCAAGGGGAAGATG
CCCGTGGTCGTCTTGCAGGATATCCTGGCCCTCAGACCGCCGGCCAGGTCTCCTCCCGCC
ACTCCTCCCAGCCAGGCTGTGCCTTCTGAGAGCGAGACACCGGAGTCCAGCCCAGAAGAG
GACTTGGCGCTGAGCCACTCGTCCTTGAGCTCTTCCTCTCCCACCAGCTCCCCCGAGGGG
CAGTCTGTGCCCACAAAGCTGCATACAGGCCCCAGCCCCTTCCCTGCCTCCACACCCGTC
TGCAGAATAACTAAGAAACTGGTCAGAGGCTCTGCAGAGAAGAACAAGATGAAACTGCAA
AGGGATAAGGAGCGTCTGCGGAGGCAGCTGAAGCTCCGGGCCGAGAAGGAGGAGAAGGAG
AAGCTGAGGGAGGAGGCCAAGAGGGCCAAGGAGGAGGCCAGGAAGAAGAGGGAGGAGGAG
AAGGAGCTGAAGGAGAAGGAGCGGCGGGAGAAGCGAGAGAAGGACGAGAAGGAGAAGGCG
GAGAAGCAGCGGCTCAAGGAGGAGAGACGCAAGGAGCGCCAGGAGGCTTTGGAGGCAAAG
CTGGAGGAGAAGCGGAAAAAGGAAGAGGAGAAACGGTTGAGAGAAGAAGAAAAGCGCATT
AAAGCCGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACCCCACAGGCCCCC
AAGACCCTGGCCGGTTCCTGTGGGAAGTTTGCCCCTTTCGAAATCAAAGAGCACATGGTC
CTCGCCCCTCGATGCCGGACTGCCTTTGATCAAGACCTCTGTGACCAGCTTGACCAGCTC
CTCCAGCAGCAGAGCAGCGAGTTCTCCTTCCTGCAAGATCTGAAAAGCCGGCGGCCGCTT
AGGTCTGGGCCCACTGTGGTGTCTAACCGGAACACAGACCTCTCTAACAGCGATGTGGTG
ATCGTGGAGAGCAGTAAAGTGGACGGTGTTCCTGAGCGGAGAAAGTTTGGCAGGATGAAG
CTCCTGCAGTTCTCTGAGAACCACCGGCCAGCATACTGGGGCACGTGGAACAAGAAGACG
ACAGTCATCCGCCCAAGGGACCCCTGGGCCCAGGACAGGGACCTCCTTGACTACGAGGTG
GACAGCGATGAGGAGTGGGAAGAGGAGGAGCCGGGAGAGTCCCTTTCCCACAGCGAAGGG
GACGATGACGATGACGTGGGAGAGGATGAGGACGAGGATGATGGTTTCTTCGTGCCCCAC
GGGTACTTGTCTGAGGATGAAGGCGTGACCGAGGAATGTGCCGACCCGGAAAATCACAAG
GTGCGCCAGAAACTGAAGGCCAAGGAGTGGGATGAGTTTCTGGCCAAGGGAAAGAGGTTC
CGCATTCTCCAGCCTGTGAAGATCGGCTGCATCTGGGCGGCCGACAAGGACGGCGGTGCT
GACCTGAAGGTGCTGCAACAGTTCACGGCCTGCCTGCTGGAGACTGTGCCCCCTGAGGAG
GAGCAGACGCCCAAGGCCTCAAAGAGAGAGAAGAGGGACCAGCAGATCCTGGCCCAGCTG
CTCCCGCTGCTGCACGGGAACGTGAATGGGAGCAAGGTGATCATTCGGGAGTTCCAGGAG
TGCTGCCGCCGAGGACTGCTCAGCAGGGACGCCGGCAGCCCGGAGGACAGTGCCGCCAGC
CCCCCGAGCCCTGGCCCTGCCCGCCCGCAGACCCCTACCGCCAGCGAGGACGTGGCTGTG
CCCTCCAAGGCCAGGCTCAAGCGGATTATTTCTGAGAACTCGGTGTATGAGAAGAGGCCC
GACTTCAGGATGTGCTGGTACGTCCACCCACAGGTGCTGAAGAGCTTCGCCCAGGAGCAC
CTGCCTGTGCCCTGCCAGTGGAGTTATGTCACCGCAGTGCCCTCGGCCACCAGGGAGGAC
AGTGGCAGTGTCCCCGCCCCGGGGCCCGGCCAGGGTATGCCCGTCTCACTCAAGAGGAAG
TCGGCGGGTAGCATGTGCATCACCCAGTTCATGAAAAAGCGCCGGCACGACGGGCAGGTT
GGCACTGGAGACCTGGACGACTTCCAGGCGGACACAGAGGAGGAGGACGACGACGAAGGC
GACTGTGTGATCATGGACATCTCTGATGTTGGGGACATCCAGGCCCCATGCGGAACCACT
TCTGGAGCTGGGGGCTCAGTGGGGATGGACACCAGTGAGAGCTTCGTGTCCCCCAGCTCG
CTTCGCCTGTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 964 |
| Molecular Weight
| 107258.0 |
| Theoretical pI
| 5.35 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Chromatin assembly factor 1 subunit A
MLEEPECGAPGARGEAAAMDCKDRPAFPVKKLIQARLPFKRLNLVPKEKIDDGLDDTGGS
RAGPVQTQLHNLETSLDHLENCHMGSDIDFRPKLVNGKGPLDNFLRSQVETSIGQAVVII
DLTEDSSNPPDNMVGHNKLNSAASSAQKNINGVPDKAGDDRGLPKARQKDELASPEEALS
EVPCKTEAGGADSGGADRRGLTQRGSPQNCPKLTGDLSMWSEKDRDGWSEAGGILFKGKM
PVVVLQDILALRPPARSPPATPPSQAVPSESETPESSPEEDLALSHSSLSSSSPTSSPEG
QSVPTKLHTGPSPFPASTPVCRITKKLVRGSAEKNKMKLQRDKERLRRQLKLRAEKEEKE
KLREEAKRAKEEARKKREEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAK
LEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMV
LAPRCRTAFDQDLCDQLDQLLQQQSSEFSFLQDLKSRRPLRSGPTVVSNRNTDLSNSDVV
IVESSKVDGVPERRKFGRMKLLQFSENHRPAYWGTWNKKTTVIRPRDPWAQDRDLLDYEV
DSDEEWEEEEPGESLSHSEGDDDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHK
VRQKLKAKEWDEFLAKGKRFRILQPVKIGCIWAADKDGGADLKVLQQFTACLLETVPPEE
EQTPKASKREKRDQQILAQLLPLLHGNVNGSKVIIREFQECCRRGLLSRDAGSPEDSAAS
PPSPGPARPQTPTASEDVAVPSKARLKRIISENSVYEKRPDFRMCWYVHPQVLKSFAQEH
LPVPCQWSYVTAVPSATREDSGSVPAPGPGQGMPVSLKRKSAGSMCITQFMKKRRHDGQV
GTGDLDDFQADTEEEDDDEGDCVIMDISDVGDIQAPCGTTSGAGGSVGMDTSESFVSPSS
LRLS
|
| External Links |
|---|
| GenBank ID Protein
| AAI47897.1 |
| UniProtKB/Swiss-Prot ID
| A6QLA6 |
| UniProtKB/Swiss-Prot Entry Name
| CAF1A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC147896 |
| GeneCard ID
| CHAF1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
