| Identification |
|---|
| BMDB Protein ID
| BMDBP02574 |
| Secondary Accession Numbers
| None |
| Name
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SMARCB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cell cycle |
| Specific Function
| Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| SMARCB1 |
| Gene Sequence
|
>1158 bp
ATGATGATGATGGCGCTGAGCAAGACCTTCGGGCAGAAGCCCGTCAAGTTCCAGCTGGAA
GATGACGGCGAGTTCTACATGATCGGCTCTGAGGTGGGAAACTACCTCCGTATGTTCCGA
GGTTCTCTGTACAAGAGATACCCCTCGCTCTGGAGGCGACTAGCCACTGTGGAAGAGAGG
AAGAAAATAGTTGCATCGTCACATGGTAAAAAAACAAAACCTAACGCTAAGGATCATGGA
TACACGACCCTGGCCACCAGCGTGACCCTGCTGAAAGCCTCCGAGGTGGAGGAGATCCTG
GACGGCAACGATGAGAAGTACAAGGCCGTGTCCATCAGCACCGAGCCCCCCACCTACCTC
AGGGAACAGAAGGCCAAGAGGAACAGCCAGTGGGTGCCCACCCTGCCCAACAGCTCGCAC
CACCTGGACGCCGTGCCCTGCTCCACCACCATCAACAGGAACCGCATGGGCCGCGACAAG
AAGCGGACCTTCCCGCTCTGCTTCGACGACCACGACCCAGCCGTGATCCACGAGAACGCG
TCCCAGCCCGAGGTGCTGGTCCCCATCCGACTGGACATGGAGATTGACGGGCAGAAGCTG
CGGGATGCCTTTACCTGGAACATGAATGAGAAGCTGATGACCCCGGAGATGTTCTCAGAG
ATTCTCTGTGACGACCTGGATCTGAACCCACTGACGTTCGTGCCAGCCATTGCCTCTGCC
ATCAGACAGCAGATCGAGTCCTACCCCACGGACAGCATCCTGGAAGACCAGTCAGACCAG
CGCGTCATTATCAAGCTGAACATCCACGTGGGGAACATCTCCTTGGTGGACCAGTTCGAG
TGGGACATGTCGGAGAAGGAGAACTCGCCCGAGAAGTTCGCTCTGAAGCTGTGCTCCGAG
CTGGGGCTGGGCGGGGAGTTCGTCACCACCATCGCCTACAGCATCCGGGGACAGCTGAGC
TGGCATCAGAAGACCTACGCCTTCAGTGAGAACCCCCTGCCCACGGTGGAGATTGCCATC
CGGAACACAGGCGACGCTGACCAGTGGTGCCCGCTGCTGGAGACCCTGACGGATGCAGAG
ATGGAGAAGAAGATCCGGGACCAGGACCGGAACACAAGGCGGATGAGGCGTCTGGCCAAC
ACGGCCCCGGCCTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 385 |
| Molecular Weight
| 44111.0 |
| Theoretical pI
| 6.13 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEER
KKIVASSHGKKTKPNAKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYL
REQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENA
SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASA
IRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSE
LGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAE
MEKKIRDQDRNTRRMRRLANTAPAW
|
| External Links |
|---|
| GenBank ID Protein
| AAX31374.1 |
| UniProtKB/Swiss-Prot ID
| Q5BIN2 |
| UniProtKB/Swiss-Prot Entry Name
| SNF5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021192 |
| GeneCard ID
| SMARCB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
