| Identification |
|---|
| BMDB Protein ID
| BMDBP02577 |
| Secondary Accession Numbers
| None |
| Name
| Sodium-dependent noradrenaline transporter |
| Synonyms
|
Not Available
|
| Gene Name
| SLC6A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in neurotransmitter:sodium symporter activity |
| Specific Function
| Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| SLC6A2 |
| Gene Sequence
|
>1848 bp
ATGCTTCTGGCGCGGATGAACCCGCAGGTGCAGCCGGAGAACGGCGGGGCGGGCCCGGGG
TCGGAGCAGCCCCCGCGGAAGCGCAAAGAAGTCTTGGTGGTGAAAGAGCGCAACGGCGTC
CAGTGCCTCCTGGCGTCCCGCGACGGCGATGAGCAGCCCCGAGAGACCTGGGGCAAGAAG
ATCGACTTCCTGCTGTCGGTGGTCGGCTTCGCTGTAGACCTGGCCAACGTGTGGCGCTTC
CCCTATCTCTGCTACAAGAACGGAGGCGGTGCCTTCCTGATCCCGTACACCCTGTTCCTC
ATCATCGCTGGGATGCCCCTCTTCTACATGGAGCTGGCTCTGGGCCAGTACAACCGGGAA
GGGGCAGCCACCGTGTGGAAGATCTGCCCATTTTTCAAAGGAGTTGGCTACGCTGTGATC
CTCATCGCCCTCTACGTTGGCTTCTACTACAACGTCATTATCGCCTGGTCCCTCTACTAC
CTCTTCTCTTCCTTCACCCCGACCCTGCCCTGGACCGACTGTGGCCACGCCTGGAACAGC
CCCAACTGCACAGACCCCAAGCTCCTCAACAGCTCCGTGCTGGGCAACCACACCAAGTAC
TCCAAGTACAAGTTCACACCTGCAGCAGAGTTTTACGAGCGTGGTGTCCTGCATCTGCAT
GAGAGCAGTGGGATTCATGACATTGGCCTGCCCCAGTGGCAGCTTTTGCTCTGTCTGATC
ATCGTTGTCATCGTCCTGTTTTTTAGCCTCTGGAAAGGAGTGAAGACATCAGGAAAGGTC
GTGTGGATCACGGCCACGCTGCCTTACCTCGTGCTGTTCGTGCTCCTGGTCCATGGCATC
ACGCTGCCCGGCGCCTCCAACGGCATCAACGCCTACCTGCACATCGACTTCTACCGCCTA
AAAGAGGCCACGGTGTGGATTGATGCTGCAACTCAGATATTCTTTTCCTTGGGGGCTGGA
TTTGGAGTCTTGATTGCATTTGCTAGTTACAACAAATTTGACAATAACTGCTACAGGGAT
GCCCTGCTGACCAGCACCATCAACTGTGTCACCAGCTTCATCTCCGGGTTCGCCATCTTC
TCCATCCTTGGTTACATGGCCCATGAACACAAGGTCAACATTGAGGATGTTGCCACTGAA
GGAGCTGGCCTAGTCTTCATCCTGTACCCAGAAGCCATTTCTACCCTCTCGGGATCCACA
TTCTGGGCCATTGTGTTCTTCATCATGCTCCTGGCTCTGGGAATTGACAGCTCGATGGGA
GGCATGGAGGCGGTCATCACGGGCCTGGCTGATGACTTCCAGGTTCTGAAGCGACACCGG
AAACTCTTCACGTTTGCTGTCTCCTTTGGAACCTTCCTTCTGGCTCTGTTTTGTATAACC
AAGGGTGGAATATATGTGCTGACCCTGTTGGACACGTTTGCGGCGGGGACCTCCATTCTT
TTTGCTGTGCTCATGGAAGCCATCGGCGTCTCCTGGTTTTATGGAGTGGACAGGTTCAGC
AACGACATCCAGCAGATGATGGGGTTCAAGCCCGGCCTGTACTGGAGACTCTGCTGGAAG
TTTGTCAGCCCTGCCTTCCTCCTGTTTGTGGTGATTGTGAGTATCATCAATTTCAAGCCA
CTCACTTACGATGACTACATCTTCCCACTCTGGGCCAACTGGGTCGGATGGGGCATCGCG
GGCTCCTCCATGGTTCTGGTGCCCGCCTACATCGTCTACAAGTTCTTCAGCACCCGGGGC
TCCATTCGAGAGAGACTGGCCTATGGCATAACTCCAGCGAGCGAGCATCACCTGGTGGCC
CAGAGGGACATCAGGCAGTTCCAATTGCAACACTGGCTGGCCATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 615 |
| Molecular Weight
| 68900.0 |
| Theoretical pI
| 8.23 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 61-86
- 91-114
- 134-164
- 232-252
- 256-280
- 305-330
- 337-360
- 401-426
- 442-462
- 464-490
- 521-543
- 547-567
|
| Protein Sequence
|
>Sodium-dependent noradrenaline transporter
MLLARMNPQVQPENGGAGPGSEQPPRKRKEVLVVKERNGVQCLLASRDGDEQPRETWGKK
IDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNRE
GAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTPTLPWTDCGHAWNS
PNCTDPKLLNSSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLI
IVVIVLFFSLWKGVKTSGKVVWITATLPYLVLFVLLVHGITLPGASNGINAYLHIDFYRL
KEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIF
SILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAIVFFIMLLALGIDSSMG
GMEAVITGLADDFQVLKRHRKLFTFAVSFGTFLLALFCITKGGIYVLTLLDTFAAGTSIL
FAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVIVSIINFKP
LTYDDYIFPLWANWVGWGIAGSSMVLVPAYIVYKFFSTRGSIRERLAYGITPASEHHLVA
QRDIRQFQLQHWLAI
|
| External Links |
|---|
| GenBank ID Protein
| CAA55645.1 |
| UniProtKB/Swiss-Prot ID
| P51143 |
| UniProtKB/Swiss-Prot Entry Name
| SC6A2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X79015 |
| GeneCard ID
| SLC6A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
