| Identification |
|---|
| BMDB Protein ID
| BMDBP02588 |
| Secondary Accession Numbers
| None |
| Name
| Ephrin-A1 |
| Synonyms
|
Not Available
|
| Gene Name
| EFNA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| EFNA1 |
| Gene Sequence
|
>618 bp
ATGGAGTTCTTCTGGGCCTCTCTCTTGGGTCTGTGCTGCAGTCTGGCCGCTGCTAACCGC
CACACCGTCTTCTGGAACAGTTCAAACCCCAAGTTTTGGAATGAGGACTACACAGTACAT
GTGCGGATAGATGACTACCTGGACATCATCTGTCCTCATTACGAGGATAACTCTGTGCCA
GATGCGGCCATGGAGCAGTACACACTGTACCTGGTGGAGCACGAGCAGTACCAGCTGTGC
CAACCCCAACCCAAGGACCATGCCCGCTGGTTCTGCAAGAGTCCCAAAGCCAAGCATGGC
CCGGAGAAGCTGTCTGAGAAGTTCCACCGCTTCACAGGGTTTACCCTCAGCAAGGATTTC
AAAGAGGGACACAGCTACTACTACATCTCCAAGCCCATCCACCACCAGGAAGACCGTTGC
TTGAGGCTGAAGGTGATGATCGCTGGCAAAATCACTCACAGCCCTCAGGCTCATCCCAAT
GCACAAGAGAAGAGACTTCCAGCAGATGACCCGGAGGTGCAGGTTCTGCATAGCATCGGG
CACAGCGCCGCTCCTCGCCTCTTCCCACTAGCCTGGGCTGTGCTGCTCCTGCCATTCCTG
CTGCTGCAAATCCCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 205 |
| Molecular Weight
| 23838.0 |
| Theoretical pI
| 7.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ephrin-A1
MEFFWASLLGLCCSLAAANRHTVFWNSSNPKFWNEDYTVHVRIDDYLDIICPHYEDNSVP
DAAMEQYTLYLVEHEQYQLCQPQPKDHARWFCKSPKAKHGPEKLSEKFHRFTGFTLSKDF
KEGHSYYYISKPIHHQEDRCLRLKVMIAGKITHSPQAHPNAQEKRLPADDPEVQVLHSIG
HSAAPRLFPLAWAVLLLPFLLLQIP
|
| External Links |
|---|
| GenBank ID Protein
| AAI02890.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZC64 |
| UniProtKB/Swiss-Prot Entry Name
| EFNA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102889 |
| GeneCard ID
| EFNA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
