1.0 2018-05-07 22:32:16 UTC 2020-05-20 21:06:26 UTC BMDBP02589 Enzyme IFNAR1 Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). BMDB0000158 L-Tyrosine 1 >1683 bp ATGCTCGCTCTCCTGGGCGCGACGACCCTGATGCTGGTCGCTGGGAGATGGGTGCTGCCC GCCGCCTCAGGGGAAGCAAATCTGAAGCCTGAAAATGTCGAGATCCACATCATTGATGAC AATTTTTTCCTGAAGTGGAACAGCAGCAGTGAGTCTGTCAAGAATGTGACTTTTTCAGCA GATTATCAAATACTAGGAACGGATAACTGGAAGAAATTGTCTGGATGTCAACATATTACT AGTACCAAATGCAACTTTTCTTCAGTCGAGCTTGAAAATGTTTTTGAAAAAATTGAATTG CGCATAAGAGCAGAAGAAGGAAACAACACTTCCACATGGTATGAGGTTGAGCCATTTGTA CCATTTCTAGAAGCTCAGATTGGTCCCCCAGATGTGCATTTAGAAGCTGAAGATAAGGCA ATAATACTGAGTATCTCTCCCCCTGGAACAAAAGATAGTATCATGTGGGCTATGGATCGT TCAAGCTTTAGGTATAGCGTCGTTATCTGGAAAAACTCTTCAAGTCTAGAAGAAAGAACG GAAACTGTTTATCCCGAAGATAAAATTTATAAACTGTCACCAGAGATTACTTATTGTTTA AAAGTTAAAGCAGAACTGCGTTTACAAAGTAGAGTTGGTTGCTATAGTCCAGTGTATTGT ATAAATACCACAGAGAGACATAAAGTACCTTCACCAGAAAATATACAAATCAATGCTGAC AACCAGATCTATGTTCTTAAGTGGGATTACCCATATGAAAACGCAACTTTTCAAGCTCAG TGGCTCCGTGCCTTTTTTAAAAAGATTCCTGGGAATCATTCAGACAAATGGAAACAAATA CCGAACTGTGAAAATGTCACAAGTACCCACTGTGTCTTTCCTCGAGAGGTTTCCTCAAGG GGAATTTACTATGTCCGTGTACGAGCATCTAATGGAAATGGTACCTCTTTTTGGTCTGAA GAGAAGGAATTTAATACTGAAATGAAAACTATCATATTTCCTCCAGTCATCAGCGTGAAA TCCGTTACTGATGATTCACTGCATGTCAGTGTTGGTGCTTCAGAAGAGTCTGAAAACATG TCTGTGAATCAGCTCTACCCGCTAATTTATGAAGTAATTTTTTGGGAAAACACTTCAAAT GCTGAGAGAAAAGTTCTAGAGAAAAGAACCAATTTTATCTTTCCTGACTTGAAACCGCTG ACTGTGTATTGTGTCAAAGCCAGAGCACTCATTGAAAATGACAGGCGGAATAAAGGGAGC AGTTTTAGTGATACTGTGTGTGAGAAAACAAAACCAGGAAATACTTCCAAAACCTGGCTT ATAGTTGGAACTTGCACTGCATTGTTTTCTATTCCTGTGGTCATTTATGTTGTGAGCGTC TTCTTGAGATGTGTCAAGTATGTGTTCTTTCCATCAAGTAAACCTCCTTCCTCTGTTGAC GAGTATTTCTCCGATCAGCCACTAAGGAATCTACTCCTTTCCACTTCTGAGGAACAAACG GAAAGATGTTTTATAATTGAAAATGCAAGCATTATTACTGAAATAGAAGAGACTGATGAA ATTGATGAAGTTCACAAAAAGTACAGTTCCCAAACTAGTCAAGATTCAGGAAACTATTCA AACGAAGATGAAAACAGTGGAAGCAAAATAAGCGAAGAGTTTCCGCAACAGGACAGTGTG TGA 560 63819.0 4.82 438-458 1-24 >Interferon-alpha/beta receptor alpha chain MLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSA DYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFV PFLEAQIGPPDVHLEAEDKAIILSISPPGTKDSIMWAMDRSSFRYSVVIWKNSSSLEERT ETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENIQINAD NQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSR GIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENM SVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGS SFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVD EYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYS NEDENSGSKISEEFPQQDSV CAA48484.1 Q04790 INAR1_BOVIN X68443 IFNAR1