| Identification |
|---|
| BMDB Protein ID
| BMDBP02594 |
| Secondary Accession Numbers
| None |
| Name
| General transcription factor II-I |
| Synonyms
|
Not Available
|
| Gene Name
| GTF2I |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| GTF2I |
| Gene Sequence
|
>2937 bp
ATGGCCCAAGTAGCAGTGTCTACCCTGCCTGTCGAAGACGAGGAGTCCTCAGAGAGCAGG
ATGGTGGTGACGTTCCTCATGTCTGCTCTTGAGTCCATGTGTAAAGAACTGGCCAAGTCC
AAGGCGGAAGTAGCGTGCATCGCAGTGTATGAGACAGACGTGTTTGTTGTTGGAACCGAG
AGAGGACGTGCTTTTGTCAACACTAGAAAGGACTTTCAGAAAGATTTTGTAAAATACTGT
GTTGAAGAAGAAGAAAAGGCTGCAGAGATGCATAAAATGAAATCTACAGCCCAGGCAAAT
CGGATGAGTGTCGATGCTGTGGAGATAGAAACACTCAGAAAAACAGTTGAGGACTATTTC
TGCTTTTGCTATGGGAAAGCTTTAGGCAAGTCAACAGTGGTGCCTGTTCCATATGAAAAG
ATGCTCCGAGATCAGTCGGCCGTGGTGGTGCAGGGGCTTCCAGAAGGAGTAGCCTTCAAA
CACCCTGAAAACTATGATCTTGCAACCCTGAAGTGGATTTTGGAGAACAAAGCAGGGATT
TCATTTATCATTAAAAGACCTTTCCTAGAGCCAAAGAAGCACCTAGGTGGTCGTGTGATG
GTTACAGATGCTGAAAGGTCAATGATATCTCCAAGTGGAAGCTGTGGCCCCGTCAAAGTA
AAAACAGAACCCTCAGAGGATTCTGGCATTTCTCTGGAAATGGCAGCTGTGACAGTGAAG
GAAGAATCTGAAGATCCTGATTACTATCAATATAACATTCAAGCAGGCCCTTCTGAAACT
GATGATGTTGATGACAAACTCCCCCTTTCGAAGTCTTTGCAAGGAAGCCATCATTCTTCA
GAGGGCAATGAAGGAACAGAAATGGAAGTACCAGCAGAAGATGATGACTATCCTCCACCT
GCCAAGAGACCAAAGAGCAGTGAACCTCCCCAGCCACCCGTCACAGAACCTGCGAATGCC
GGCAAACGGAAAGTGAGGGAGTTCAACTTCGAGAAATGGAATGCTCGAATTACTGATCTG
CGTAAACAAGTTGAAGAGTTGTTTGAAAGAAAGTATGCTCAAGCTATAAAAGCCAAAGGT
CCTGTGACGATCCCGTACCCTCTTTTCCAGTCCCATGTGGAAGATCTTTATGTAGAAGGA
CTTCCAGAAGGAATCCCCTTTAGAAGGCCATCAACTTATGGAATCCCTCGCCTTGAGAGG
ATATTACTTGCAAAGGAAAGGATTCGTTTTGTGATTAAGAAGCATGAACTTTTGAATTCA
ACACGTGAAGACTTACAGCTTGATAAACCAGCTTCAGGAGTCAAGGAAGAGTGGTATGCC
AGAATCACTAAGTTACGAAAGATGGTAGATCAGCTTTTCTGTAAAAAATTTGCTGAAGCC
TTAGGGAGCACCGAAGCTAAGGCTGTACCTTACCAGAAATTTGAAGCACACCCTAATGAC
CTCTACGTGGAAGGACTGCCAGAAAACATTCCTTTTAGAAGTCCCTCGTGGTATGGGATC
CCAAGGCTGGAAAAGATTATTCAAGTGGGCAATCGAATTAAATTTGTTATTAAAAGACCA
GAGCTTCTGACGCACAGCACTACTGAAGTTACTCAGCCCAGAACGAATACACCAGTCAAA
GAAGATTGGAATGTCAGAATTACCAAGCTACGGAAGCAAGTGGAAGAGATTTTTAATTTG
AAATTTGCTCAAGCTCTTGGACTCACAGAAGCAGTAAAAGTACCATACCCGGTGTTTGAA
TCAAACCCCGAGTTCCTCTATGTAGAAGGCTTGCCAGAAGGAATTCCCTTTCGAAGCCCT
ACCTGGTTTGGAATTCCAAGACTGGAAAGGATTGTCCGTGGAAGTAATAAAATCAAGTTT
GTTGTTAAAAAACCTGAACTAGTTATTTCCTACTTGCCTCCTGGAATGGCTAGTAAAATA
AACACTAAAGCTTTGCAGTCCCCGAAAAGACCACGAAGCCCCGGGAGTAATTCGAAAGTT
CCTGAAATTGAGGTCACTGTGGAAGGCCCTAATAATAGCAATCCTCAAACCTCAGCCGTT
CGAACCCCTACCCAGACGAATGGTTCTAATGTTCCCTTCAAGCCTCGAGGGAGAGAGTTT
TCCTTTGAGGCCTGGAATGCCAAAATCACAGACCTAAAACAGAAAGTTGAAAATCTTTTC
AATGAAAAATGTGGTGAAGCTCTTGGCCTTAAACAAGCTGTGAAAGTGCCGTTCGCGTTA
TTTGAGTCTTTCCCAGAAGACTTTTATGTGGAAGGCTTACCCGAGGGTGTGCCATTCCGA
CGACCGTCTACTTTTGGCATTCCAAGGCTGGAGAAGATACTCAGAAACAAAGCCAAAATT
AAGTTCATCATTAAAAAGCCAGAAATGTTTGAGACTGCAATTAAGGAGAGCACCTCCTCA
TCTAAGAGCCCTCCAAGAAAAATCAATTCATCACCCAGTGTTAATACTACTGCATCAGGT
GTTGAAGACCTTAACATCATTCAGGTGACAATTCCAGACGATGATAATGAAAGACTATCA
AAAGTTGAAAAAGCTCGACAGCTAAGAGAGCAAGTTAATGACCTCTTCAGTCGAAAATTT
GGTGAAGCCATTGGGATGGGTTTCCCCGTGAAGGTTCCTTACAGGAAAATCACAATTAAC
CCTGGCTGTGTGGTGGTTGATGGCATGCCCCCCGGAGTGTCATTCAAAGCCCCCAGCTAT
CTGGAAATCAGCTCCATGAGAAGGATCTTAGATTCTGCTGAGTTCATTAAATTCACAGTC
ATTAGACCATTTCCAGGACTTGTGATTAATAACCAGTTGGTTGATCAGAATGAGTCAGAA
GGCCCAGTGATCCAAGAATCAGCTGAGCCAACCCAGTTGGAGGTTCCTGCAACCGAAGAA
ATAAAGGAGACTGATGGAAACTCCCAAATCAAGCAAGAACCAGACCCTACGTGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 978 |
| Molecular Weight
| 110125.0 |
| Theoretical pI
| 7.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>General transcription factor II-I
MAQVAVSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTE
RGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTAQANRMSVDAVEIETLRKTVEDYF
CFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHLGGRVMVTDAERSMISPSGSCGPVKVKTEPSEDSGISLEMAAVTVK
EESEDPDYYQYNIQAGPSETDDVDDKLPLSKSLQGSHHSSEGNEGTEMEVPAEDDDYPPP
AKRPKSSEPPQPPVTEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQAIKAKG
PVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHELLNS
TREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPND
LYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVK
EDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSP
TWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKALQSPKRPRSPGSNSKV
PEIEVTVEGPNNSNPQTSAVRTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENLF
NEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKI
KFIIKKPEMFETAIKESTSSSKSPPRKINSSPSVNTTASGVEDLNIIQVTIPDDDNERLS
KVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSY
LEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQNESEGPVIQESAEPTQLEVPATEE
IKETDGNSQIKQEPDPTW
|
| External Links |
|---|
| GenBank ID Protein
| AAI51388.1 |
| UniProtKB/Swiss-Prot ID
| A7MB80 |
| UniProtKB/Swiss-Prot Entry Name
| GTF2I_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC151387 |
| GeneCard ID
| GTF2I |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
