1.0 2018-05-07 22:32:18 UTC 2020-05-20 21:06:22 UTC BMDBP02596 Enzyme CD163 Involved in scavenger receptor activity Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). BMDB0000158 L-Tyrosine 5 1129 121806.0 5.93 1040-1060 1-40 >Scavenger receptor cysteine-rich type 1 protein M130 MVLHDNSGSAGFKRCSVHFGPFTLAVVSVLYACLITSALGGTDKELRLVAGQTKCSGRVE VKVQEEWGTVCNTGWDLAAVSVVCKQLGCPSVIKATGWTNSSAGTGRIWMDHVSCRGNES ALWDCKHEGWGKHNCTHQQDVGVTCSDGSDLEMRLMNGGNRCSGRIEIKFQGQWGTVCDD NFNLDHASVVCKQLGCGSAVSFSGSANFGEGSGPIWFDDLVCHGNESALWNCRHEGWGKH NCDHAEDAGVICLEGADLSLRLVDGVTKCSGRLEVRFQGEWGTVCDDGWDSDDAAVACQQ LGCPTAITAVGRVNASEGTGHIWLDSVSCQGHESAVWQCRHHEWGKHYCNHNEDAGVTCS DGSDLELRLKGGGSRCAGTVEVEIQKLIGKVCDRSWGLKEADVVCKQLGCGSALRTSYQV YSKIQATNTWLFLNNCNGNETSIWDCKNWQWGGLSCEHYHEAKVTCSAHREPRLVGGDIP CSGRVEVKHGDTWGTICDSDFSLESASVLCRELECGSVVSILGGAHFGEGNGQIWAEEFQ CEGNESHLSLCPVAPRLDGTCSHSKDIGVVCSRYTEVRLVGGNTPCEGRVEVKILGTWGP LCNSHWDMEDAHVLCQQLKCGVAASIPGRAPFGKGSGQPWRHMFHCTGTEQHMGDCPVTA LGASLCPEGQVASVICSGNRSQTLYPCNSSSSDPESSVVLEENGVPCIGSGQLRLVNGGG RCAGRIEVYHEGSWGTICDDSWDLDDAHVVCRQLGCGVAINATGSAHFGEGSGPIWLDEV NCNGKEPRISQCRSHGWGRQNCRHKEDAGVICSEFMSLRLISDSSSETCAGRLEVFYNGA WGSVGKSDMSATTVGVVCRQLGCTDKGSIRPAPSDKVENRYMWVDNVRCPKGPETLWQCP SSPWKRRLASPSEETWITCADKIRLQEGTTNCSGRVEVWHGGSWGTVCDDSWDLNDAQVV CRQLGCGLALEAGKEAAFGQGTGPIWLNEVKCKGNESSLWDCPARSWGHSDCGHKEDASV KCSEIAESKGSVKAAGHSSTVALGILGVILLAFLIATLLWIQRRRQRQRLAVSSRGENSV HEIQYREMNSCLKADDLDLYNSSGLWVLRGSIALGFRLVTAAEAERHST ACS87934.1 P85521 C163A_BOVIN GQ184570 CD163