| Identification |
|---|
| BMDB Protein ID
| BMDBP02599 |
| Secondary Accession Numbers
| None |
| Name
| Cytokine-inducible SH2-containing protein |
| Synonyms
|
Not Available
|
| Gene Name
| CISH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling cascade |
| Specific Function
| SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| CISH |
| Gene Sequence
|
>765 bp
ATGGTCCTCTGCGTTCAGGGACTTTGTCCTTTGCTGGCCGTGGAGCAGATTGGGCAGCGG
CCCCTGTGGGCCCAGTCCCTGGAGCTGCCCCAGCAAGTTATGCAGCCTTTGTCTGCTGGC
GCCTTCCTGGAGGAGGCAGTAGAGGAGTCCCCAGCCCAGCCAGAGAGGGAGCCCAAGGTG
GTGGACCCCGAGGAGGACCTGCTGTGCATAGCCAAGACCTTCTCCTACCTTCGGGAATCT
GGCTGGTACTGGGGTTCCATTACGGCCAGTGAGGCCCGGCAACACCTTCAGAAGATGCCA
GAGGGCACCTTCCTGGTACGTGACAGCACCCACCCCAGCTACCTGTTCACACTGTCCGTC
AAGACCACCCGCGGGCCCACCAACGTGCGCATTGAGTACGCCGACTCCAGCTTCCGCCTG
GACTCCAACTGCCTGTCCAGGCCTCGCATCCTGGCCTTCCCAGATGTGGTGAGCCTGGTC
CAGCACTACGTGGCCTCCTGTGCTGCAGACACCCGGAGTGACAGTCCCGACCTTGCCACC
ACCCCGGCCCTGCCCACCCCGAAGGAAGATGCGCCCGGTGACCCAGCCCTGCCCGCCACG
GCCGTTCACCTGAAACTGGTACAGCCCTTTGTGCGCAGGAGCAGCACCCGGAGCCTGCAG
CACCTGTGCCGCCTGGTCATCAACCGCCTGGTGGTCGACGTGGACTGCCTGCCGCTTCCC
CGGCGCATGGCTGACTACCTCCGACAATACCCCTTCCAGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 254 |
| Molecular Weight
| 28397.0 |
| Theoretical pI
| 6.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytokine-inducible SH2-containing protein
MVLCVQGLCPLLAVEQIGQRPLWAQSLELPQQVMQPLSAGAFLEEAVEESPAQPEREPKV
VDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV
KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDLAT
TPALPTPKEDAPGDPALPATAVHLKLVQPFVRRSSTRSLQHLCRLVINRLVVDVDCLPLP
RRMADYLRQYPFQL
|
| External Links |
|---|
| GenBank ID Protein
| AAI13308.1 |
| UniProtKB/Swiss-Prot ID
| Q2HJ53 |
| UniProtKB/Swiss-Prot Entry Name
| CISH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC113307 |
| GeneCard ID
| CISH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
