| Identification |
|---|
| BMDB Protein ID
| BMDBP02619 |
| Secondary Accession Numbers
| None |
| Name
| Voltage-gated potassium channel subunit beta-2 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNAB2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarity). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| KCNAB2 |
| Gene Sequence
|
>1104 bp
ATGTATCCGGAATCAACCACAGGCTCCCCAGCTCGGCTCTCCCTGCGGCAGACGGGCTCC
CCCGGCATGATCTACAGTACTCGGTATGGGAGCCCCAAAAGACAGCTCCAGTTTTACAGG
AACCTGGGCAAGTCGGGCCTGCGGGTCTCCTGCCTGGGGCTCGGAACATGGGTGACCTTC
GGAGGCCAGATCACTGACGAGATGGCAGAGCAGCTAATGACCTTGGCCTACGACAATGGC
ATCAACCTCTTCGATACCGCAGAAGTCTACGCGGCGGGCAAAGCTGAAGTGGTGTTAGGA
AACATCATCAAGAAGAAGGGATGGAGACGATCCAGCCTCGTCATCACCACCAAGATCTTC
TGGGGAGGAAAAGCCGAGACGGAGAGGGGCCTTTCCAGGAAGCACATAATAGAAGGTCTG
AAAGCTTCCCTGGAGCGGCTGCAGTTGGAGTATGTGGATGTGGTATTTGCCAACCGCCCG
GACCCCAACACACCCATGGAAGAGACGGTGCGTGCCATGACTCACGTCATTAACCAGGGG
ATGGCCATGTACTGGGGCACATCGCGCTGGAGCTCCATGGAGATCATGGAGGCCTACTCC
GTGGCCCGGCAGTTCAACCTGATCCCACCCATCTGCGAGCAGGCGGAGTACCACATGTTC
CAGCGGGAGAAGGTAGAGGTGCAGCTGCCGGAGCTCTTCCACAAGATAGGAGTGGGCGCC
ATGACCTGGTCCCCTCTGGCCTGCGGCATCGTTTCCGGAAAGTACGACAGTGGCATCCCG
CCCTACTCTAGAGCCTCTTTGAAGGGATACCAGTGGCTGAAGGACAAGATCCTGAGTGAG
GAGGGCCGGCGCCAGCAGGCCAAGCTGAAGGAACTACAGGCCATCGCCGAGCGCCTGGGC
TGTACCCTCCCCCAGCTGGCCATCGCCTGGTGCCTGAGGAACGAGGGGGTCAGCTCCGTG
CTCCTGGGTGCTTCCAGCGCAGACCAGCTGATGGAGAACATTGGAGCAATACAGGTCCTT
CCAAAACTGTCGTCTTCCATCATCCACGAGATCGATAGTATTTTGGGCAATAAGCCCTAC
AGCAAAAAGGACTACAGATCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 367 |
| Molecular Weight
| 40985.0 |
| Theoretical pI
| 9.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Voltage-gated potassium channel subunit beta-2
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
MAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
CTLPQLAIAWCLRNEGVSSVLLGASSADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
SKKDYRS
|
| External Links |
|---|
| GenBank ID Protein
| CAA49999.1 |
| UniProtKB/Swiss-Prot ID
| Q27955 |
| UniProtKB/Swiss-Prot Entry Name
| KCAB2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X70661 |
| GeneCard ID
| KCNAB2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
