1.0 2018-05-07 22:32:33 UTC 2020-05-20 21:10:16 UTC BMDBP02649 Enzyme KCNJ12 Involved in inward rectifier potassium channel activity Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). Muscle/Heart Contraction SMP0119378 BMDB0000586 Potassium 19 >1284 bp ATGACTGCGTCCGGCCGCACAAACCCCTACAGCATCGTGTCTTCAGAGGAGGACGGGCTG CACTTGGTCACCATGTCGGGCGCCAACGGCTTCGGCAATGGCAAGGTGCACACGCGGCGC AGGTGCCGGAATCGCTTCGTCAAGAAGAATGGCCAGTGCAACATCGAGTTCGCCAACATG GATGAGAAGTCGCAGCGCTACCTGGCGGACATGTTCACCACGTGCGTGGACATCCGCTGG CGCTACATGCTGCTCATCTTCTCGCTGGCCTTCCTCGCCTCCTGGTTGCTGTTCGGGGTC ATCTTCTGGGTCATTGCTGTGGCCCATGGGGACCTGGAGCCTGCTGAAGCCCATGGCCGC ACGCCGTGCGTGCTGCAGGTGCATGGCTTCATGGCGGCCTTCCTCTTCTCCATTGAGACG CAGACCACCATTGGCTACGGGCTGCGCTGCGTGACCGAGGAGTGCCCGGTGGCGGTGTTC ATGGTGGTGGCGCAGTCCATCGTGGGCTGCATCATCGACTCCTTCATGATTGGCGCCATC ATGGCCAAGATGGCGCGGCCCAAGAAGCGTGCACAGACGCTGCTATTCAGCCACAATGCG GTGGTGGCGCTGCGTGACGGCAAGCTCTGCCTCATGTGGCGCGTGGGCAACCTACGCAAG AGCCATATTGTGGAGGCCCACGTGCGGGCCCAGCTCATCAAGCCCCGGGTCACGGAGGAG GGCGAGTACATCCCGCTGGACCAGATCGACATTGATGTAGGCTTTGACAAGGGCCTGGAC CGCATCTTCCTGGTGTCTCCCATCACCATCCTGCACGAGATCGACGAGGCCAGCCCTCTG TTTGGCATCAGCCGGCAGGACCTGGAAACGGATGACTTCGAGATCGTTGTCATCCTGGAG GGCATGGTGGAGGCCACGGCCATGACCACGCAGGCCCGCAGCTCCTACCTGGCCAACGAG ATCCTGTGGGGCCACCGCTTTGAGCCTGTCCTCTTTGAGGAGAAAAACCAGTACAAGATC GACTACTCGCATTTCCACAAGACGTACGAGGTGCCATCCACACCCCGCTGCAGTGCCAAG GACCTAGTGGAGAACAAGTTCTTGCTGCCAAGCACCAACTCCTTCTGCTACGAGAATGAG CTGGCCTTCCTGAGCCGCGACGAGGAGGACGAGGTGGACGGAGAGCAAGACAGCCTCGGC CCCCAGGCCAGGCGCGACTTTGACAGGCCGCAGGCCGGCACAGCCCTTGAGCAGCGGCCT TACAGACGGGAGTCTGAGATCTGA 427 48442.0 5.63 83-107 157-181 None >ATP-sensitive inward rectifier potassium channel 12 MTASGRTNPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANM DEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEAHGR TPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAI MAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEE GEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILE GMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAK DLVENKFLLPSTNSFCYENELAFLSRDEEDEVDGEQDSLGPQARRDFDRPQAGTALEQRP YRRESEI AAY53910.1 Q4TZY1 KCJ12_BOVIN DQ023214 KCNJ12