| Identification |
|---|
| BMDB Protein ID
| BMDBP02657 |
| Secondary Accession Numbers
| None |
| Name
| Voltage-gated potassium channel subunit beta-1 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNAB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (By similarity). Accelerates KCNA4 channel closure (By similarity). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (By similarity). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (By similarity). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| KCNAB1 |
| Gene Sequence
|
>1206 bp
ATGCAAGTCTCCATAGCCTGCACCGAGCATAATTTGAAGAGTCGGAATGGTGAGGACAGA
CTTCTGAGCAAGCAGAGCTCCACCGCCCCCAATGTGGTGAACGCAGCCCGGGCCAAATTC
CGCACGGTTGCTATCATCGCTCGCAGCCTAGGGACCTTCACCCCTCAGCATCACATCTCT
CTCAAAGAGTCCACTGCAAAGCAGACTGGCATGAAATATAGGAATCTTGGAAAATCAGGA
CTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGAT
GAGGTTGCTGAACGGCTGATGACAATCGCATATGAGAGCGGAGTGAATCTCTTTGATACA
GCCGAGGTCTATGCCGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAA
GGCTGGAGGAGGTCCAGCCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAA
ACAGAAAGAGGGTTGTCAAGAAAACATATTATTGAAGGACTTAAGGGCTCTCTCCAGAGG
CTGCAGCTCGAGTATGTGGATGTAGTTTTTGCAAATCGACCGGACAGTAACACCCCCATG
GAAGAAATTGTTCGTGCCATGACACATGTGATAAACCAAGGAATGGCCATGTACTGGGGA
ACTTCTCGCTGGAGTGCCATGGAGATCATGGAAGCCTACTCTGTAGCAAGACAATTCAAC
ATGATCCCACCAGTCTGTGAACAAGCTGAATACCACCTTTTCCAGAGAGAGAAAGTAGAG
GTTCAGCTACCAGAGCTCTACCATAAAATAGGAGTTGGAGCAATGACATGGTCTCCACTG
GCTTGTGGAATCATCTCAGGAAAATATGGAAACGGGGTGCCTGAAAGTTCTAGGGCTTCG
CTGAAGTGCTACCAGTGGTTGAAGGAAAGAATTGTGAGTGAAGAAGGGAGAAAACAGCAA
AACAAGCTGAAAGATCTTTCCCCGATCGCGGAGCGTCTGGGATGCACGCTACCTCAGCTA
GCCGTGGCGTGGTGCCTGAGAAATGAGGGTGTGAGTTCCGTTCTCCTGGGATCATCCACT
CCTGAGCAGCTCATTGAAAACCTCGGTGCCATTCAGGTTCTCCCAAAGATGACATCACAC
GTGGTAAACGAGATTGATAACATATTGCGCAACAAGCCCTACAGCAAAAAGGACTATAGA
TCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 401 |
| Molecular Weight
| 44710.0 |
| Theoretical pI
| 9.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Voltage-gated potassium channel subunit beta-1
MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHIS
LKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDT
AEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQR
LQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFN
MIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRAS
LKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSST
PEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
|
| External Links |
|---|
| GenBank ID Protein
| AAY82471.1 |
| UniProtKB/Swiss-Prot ID
| Q4PJK1 |
| UniProtKB/Swiss-Prot Entry Name
| KCAB1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| DQ083328 |
| GeneCard ID
| KCNAB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
