1.0 2018-05-07 22:32:38 UTC 2020-05-20 21:08:39 UTC BMDBP02667 Enzyme KCTD13 Involved in voltage-gated potassium channel activity Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. Protein modification Protein ubiquitination BMDB0000586 Potassium 25 >990 bp ATGTCCGCCGAGGCCTCGGGCCCGGCGGCGGCCGAGGCGCCGTCCCTGGAGGTCGCTAAG CCCTCGGAACTGGAGCCTGGCTCCGCCGCCTACGGTCTCAAGCCACTGACCACGAACAGC AAGTACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTGCGCACCCTCACC GGACAGGACACCAGGCTCAAGGCCATGTTCAGCGGCCGCGCGGAGGTGCTCACGGACGCC GGAGGCTGGGTGCTGATTGACCGGAGCGGCCGCCATTTTGGTACAATCCTCAACTACCTG CGGGACGGGTCTGTGCCTCTGCCTGAAAGCACCAGAGAACTGGGGGAGCTGCTGGGCGAA GCCCGCCACTACCTGGTGCAGGGACTGATTGAGGACTGCCAACTGGCACTGCAGCAAAAA AGGGAGAACGTATCCCCGCTGTGCCTCATCCCCACGGTGACATCTCCCCGGGAGGAGCAG CAGCTCCTGGCCAGCACCTCCAAGCCCGTGGTGAAGCTCCTGCACAACCGCAGTAACAAC AAGTACTCCTACACCAGCACTTCAGACGACAACCTACTTAAGAACATCGAGCTGTTTGAC AAACTGGCCCTGCGCTTCCACGGGCGGCTGCTTTTCCTCAAGGATGTTCTGGGGGACGAG ATCTGCTGCTGGTCTTTCTACGGGCAGGGCCGCAAAATCGCCGAGGTGTGCTGCACCTCC ATTGTCTATGCCACGGAGAAGAAGCAGACCAAGGTGGAATTCCCAGAGGCCCGGATCTTT GAGGAGACCCTGAACATCCTGATCTACGAGACTCCCCGAGGCCCAGACCCAGCCCTCCTG GAGGCCACAGGAGGTGCAGCTGGAGGTGGTGGAGCCAGCCGAGGGGAGGATGAGGACAAC CGAGAGCACCGTGTCCGCAGGATCCACGTCCGGCGCCACATCACGCATGATGAGCGTCCT CACGGCCAACAGATTGTCTTCAAGGACTGA 329 36425.0 7.05 None >BTB/POZ domain-containing protein KCTD13 MSAEASGPAAAEAPSLEVAKPSELEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLT GQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGE ARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNN KYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTS IVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDN REHRVRRIHVRRHITHDERPHGQQIVFKD AAI11243.1 Q2T9W0 BACD1_BOVIN BC111242 KCTD13