| Identification |
|---|
| BMDB Protein ID
| BMDBP02680 |
| Secondary Accession Numbers
| None |
| Name
| Cyclic nucleotide-gated cation channel alpha-3 |
| Synonyms
|
Not Available
|
| Gene Name
| CNGA3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Could be responsible for cGMP-induced calcium entry in cells other than sensory cells. Might be involved in chemotaxis of sperm. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| CNGA3 |
| Gene Sequence
|
>2121 bp
ATGGCCAAGATTAGCACCCAATACTCCCACCCCACCAGGACACACCCCTCGGTCAGGACC
ATGGACAGAGATCTGGATTGCATTGAAAACGGTCTCAGCAGGACCCACTTGCCATGCGAG
GAGACATCGTCAGAACTGCAGGAAGGCATTGCCATGGAGACTAGAGGACTGGCTGAATCC
AGGCAAAGCTCCTTCACCAGCCAGGGTCCCACCAGGTTGTCACGCCTCATCATCTCGCTC
CGTGCCTGGAGCGCCAGGCACTTACACCAGGAGGACCAGAGGCCCGACTCTTTCCTGGAG
CGTTTCCGCGGAGCTGAGCTCCAAGAGGTGTCTAGCCGAGAAAGCCATGTCCAGTTCAAT
GTGGGCAGCCAGGAGCCACCAGACAGAGGGAGAAGTGCCTGGCCCCTGGCCAGAAACAAC
ACCAACACCTGCAACAACTCGGAGAAGGATGACAAGGCGAAAAAGGAGGAGAAAGAGAAA
AAGGAAGAGAAAAAGGAGAACCCCAAGAAAGAGGAGAAGAAGAAGGACAGCGTTGTGATG
GACCCTTCCAGCAACATGTACTACCACTGGCTGACTGTCATCGCCGTGCCTGTCTTCTAC
AACTGGTGTCTGCTCGTGTGCAGGGCCTGTTTCGATGAGCTCCAGTCCGAGCACCTGATG
CTTTGGCTGGTCCTGGACTACTCAGCAGACATCCTCTATGGCATGGATATGCTGGTCCGA
GCCCGGACAGGCTTCCTGGAGCAAGGCCTGATGGTCATGGACGCCAGCCGGCTGTGGAAG
CACTACACACAGACCTTGCACTTCAAGCTGGACGTGTTGTCCCTGGTGCCCACAGACCTG
GCTTATTTTAAGCTGGGCATGAACTACCCAGAACTGAGGTTCAACCGCCTCCTGAAGTTG
GCCCGGCTCTTCGAATTCTTTGACCGCACGGAGACAAGGACCAACTACCCCAACATGTTC
AGGATCGGGAACTTGGTCTTGTACATCCTCATCATCATCCACTGGAATGCCTGCATCTAC
TTTGCCATTTCCAAGTTCATTGGTTTCGGGACCGACTCCTGGGTCTACCCAAACGTCTCC
AACCCAGAGTATGGGCGCCTCTCCAGAAAGTACATTTACAGTCTCTACTGGTCCACCTTG
ACCCTGACCACCATTGGGGAGACCCCGCCCCCCGTAAAAGACGAGGAATATCTCTTTGTG
GTCATCGACTTCCTGGTGGGCGTCCTGATTTTTGCCACCATCGTGGGCAACGTGGGCTCC
ATGATCTCAAACATGAATGCTTCACGGGCCGAGTTCCAGGCCAAGATCGATTCCATCAAG
CAGTACATGCAGTTCCGCAAGGTGACCAAGGACTTGGAGACACGGGTGATCCGCTGGTTC
GACTACCTGTGGGCCAATAAGAAGACAGTGGATGAGAAGGAGGTGCTCAAGAGCCTCCCC
GACAAGCTGAAGGCCGAGATCGCCATCAACGTGCACCTGGACACCCTGAGGAAGGTCCGA
ATCTTCCAGGACTGCGAGGCGGGGCTGCTGGTGGAGCTGGTGCTGAAGCTGCGGCCGGCA
GTGTTCAGCCCCGGGGACTACATCTGCAAGAAGGGGGACATCGGGAGGGAGATGTACATT
ATCAAGGAGGGCAAGCTGGCCGTGGTGGCCGAGGACGGCATCACCCAGTTCGTGGTCCTC
GGCGACGGGAGTTATTTCGGGGAGATCAGCATCTTGAACATCAAGGGGAGCAAGTCCGGG
AACCGCCGCACGGCCAACATCAGGAGCATCGGCTACTCGGACCTGTTCTGCCTCTCCAAG
GACGACCTGATGGAGGCGCTCACCGAGTACCCCGAGGCCAAGAAGGCGCTGGAGGAGAAA
GGGCGGCAGATCCTCATGAAGGACAACCTGATCGACGAGGAGCTGGCCAAGGCCGGGGCA
GACCCCAAGGACATCGAGGAGAAGGTGGAGCACCTCGAGACCTCCCTGGACTCCCTGCAG
ACCAGGTTTGCGCGGCTCCTGGCTGAGTACAACGCCACCCAGATGAAGGTGAAGCAGCGG
CTCAGCCAGTTGGAAAGCCAGGTGAAGATGGGCCTCCCGCCTGATGGCGATGCTCCGCAA
ACTGAGGCCAGTCAGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 706 |
| Molecular Weight
| 81132.0 |
| Theoretical pI
| 6.84 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cyclic nucleotide-gated cation channel alpha-3
MAKISTQYSHPTRTHPSVRTMDRDLDCIENGLSRTHLPCEETSSELQEGIAMETRGLAES
RQSSFTSQGPTRLSRLIISLRAWSARHLHQEDQRPDSFLERFRGAELQEVSSRESHVQFN
VGSQEPPDRGRSAWPLARNNTNTCNNSEKDDKAKKEEKEKKEEKKENPKKEEKKKDSVVM
DPSSNMYYHWLTVIAVPVFYNWCLLVCRACFDELQSEHLMLWLVLDYSADILYGMDMLVR
ARTGFLEQGLMVMDASRLWKHYTQTLHFKLDVLSLVPTDLAYFKLGMNYPELRFNRLLKL
ARLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNVS
NPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGS
MISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLP
DKLKAEIAINVHLDTLRKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYI
IKEGKLAVVAEDGITQFVVLGDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSK
DDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELAKAGADPKDIEEKVEHLETSLDSLQ
TRFARLLAEYNATQMKVKQRLSQLESQVKMGLPPDGDAPQTEASQP
|
| External Links |
|---|
| GenBank ID Protein
| CAA61759.1 |
| UniProtKB/Swiss-Prot ID
| Q29441 |
| UniProtKB/Swiss-Prot Entry Name
| CNGA3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X89600 |
| GeneCard ID
| CNGA3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
