1.0 2018-05-07 22:32:48 UTC 2020-05-20 21:07:37 UTC BMDBP02704 Enzyme SCIN Involved in actin filament binding Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:1651929, PubMed:1847925, PubMed:8780652). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (PubMed:8780652). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity). BMDB0000464 Calcium 4 >2148 bp ATGGCCCAGGGGCTGTACCACGAGGAGTTCGCCCGCGCGGGCAAGCGGGCGGGGCTGCAG GTCTGGAGAATTGAGAAGCTGGAGCTGGTGCCGGTGCCCGAGAGCGCGTATGGCAACTTC TACGTCGGGGATGCCTACCTGGTGCTCCACACGACGCAGGCCAGCCGGGGCTTCACCTAC CGCCTGCACTTCTGGCTGGGAAAGGAGTGTACTCAGGATGAAAGCACAGCAGCTGCCATC TTTACTGTTCAGATGGATGACTATTTGGGTGGCAAACCTGTGCAGAACAGAGAACTTCAA GGCTATGAGTCTACGGATTTTGTTGGCTACTTTAAAGGAGGTCTGAAATACAAGGCTGGC GGTGTGGCGTCTGGACTCAATCATGTGCTTACAAATGACTTGACTGCTCAGAGGCTCCTG CATGTGAAAGGTCGGAGAGTCGTCAGGGCCACGGAAGTTCCCCTAAGCTGGGACAGTTTC AACAAGGGTGACTGCTTCATCATTGACCTTGGCACTGAAATTTACCAGTGGTGTGGATCT TCTTGCAACAAGTACGAGCGCCTGAAGGCCAGCCAGGTTGCCATCGGCATTCGGGACAAT GAAAGGAAAGGCAGAGCTCAGCTGATTGTGGTAGAAGAAGGGAGTGAACCATCAGAGCTT ACAAAGGTATTAGGGGAAAAGCCAAAGCTTAGGGATGGAGAAGATGATGATGACATCAAA GCAGATATAACTAATAGGAAAATGGCTAAACTCTACATGGTTTCAGATGCCAGTGGCTCC ATGAAAGTGAGTCTGGTGGCAGAAGAAAACCCCTTCTCCATGGCGATGCTTCTGTCTGAA GAATGCTTCATTTTGGACCACGGTGCTGCAAAACAGATTTTTGTATGGAAAGGTAAAGAT GCTAATCCCCAGGAGAGAAAGGCTGCCATGAAGACAGCTGAGGAATTCCTACAGCAAATG AATTATTCTACGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTC AAACAGTTCTTTAAGGACTGGAGAGATAGAGATCAGAGCGATGGCTTCGGGAAAGTGTAT GTCACAGAAAAAGTGGCTCACGTAAAACAAATTCCATTTGATGCCTCAAAATTGCACAGC TCCCCACAAATGGCAGCCCAGCATCACGTGGTGGATGACGGTTCTGGCAAAGTGCAGATT TGGCGTGTAGAAAACAACGGTAGGGTCGAAATTGACCGAAACTCGTATGGTGAATTCTAT GGTGGTGATTGCTACATTATACTTTACACTTATCCCAGAGGACAGATTATCTACACCTGG CAAGGAGCAAATGCCACACGGGATGAGCTGACAACCTCCGCATTCCTGACTGTTCAGTTG GATAGATCCCTCGGGGGACAGGCTGTGCAGATTCGAGTCTCCCAAGGCAAAGAACCTGCT CACCTGCTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAACGGAACATCAAAG AAAGAAGGTCAGGCACCAGCCCCCCCTATACGCCTCTTTCAAGTCCGAAGAAACCTGGCT TCGATCACCAGAATTATGGAGGTAGATGTTGATGCAAACTCATTGAATTCCAATGATGTT TTTGTCCTGAAACTGCGACAAAATAATGGCTACATCTGGATAGGAAAAGGCTCCACACAG GAGGAGGAGAAAGGAGCAGAGTACGTGGCAAGCGTCCTCAAATGCAAAACTTCGACGATT CAGGAAGGCAAGGAACCAGAGGAGTTTTGGAATTCCCTTGGAGGGAAAAAAGACTACCAG ACCTCTCCTCTGCTAGAATCCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCC AACAAAACTGGAAGATTCATTATTGAAGAGGTTCCAGGAGAGTTCACCCAGGATGATTTA GCAGAAGATGATGTCATGCTGTTAGATGCTTGGGAACAGATTTTTATTTGGATTGGAAAA GATGCCAATGAAGTTGAGAAATCAGAATCTCTGAAGTCTGCCAAAATATACCTTGAGACC GACCCTTCTGGAAGAGACAAGAGGACGCCAATTGTCATCATAAAACAGGGTCATGAGCCA CCTACTTTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAGGTGGTAA 715 80578.0 5.73 None >Adseverin MAQGLYHEEFARAGKRAGLQVWRIEKLELVPVPESAYGNFYVGDAYLVLHTTQASRGFTY RLHFWLGKECTQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESTDFVGYFKGGLKYKAG GVASGLNHVLTNDLTAQRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGS SCNKYERLKASQVAIGIRDNERKGRAQLIVVEEGSEPSELTKVLGEKPKLRDGEDDDDIK ADITNRKMAKLYMVSDASGSMKVSLVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKD ANPQERKAAMKTAEEFLQQMNYSTNTQIQVLPEGGETPIFKQFFKDWRDRDQSDGFGKVY VTEKVAHVKQIPFDASKLHSSPQMAAQHHVVDDGSGKVQIWRVENNGRVEIDRNSYGEFY GGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPA HLLSLFKDKPLIIYKNGTSKKEGQAPAPPIRLFQVRRNLASITRIMEVDVDANSLNSNDV FVLKLRQNNGYIWIGKGSTQEEEKGAEYVASVLKCKTSTIQEGKEPEEFWNSLGGKKDYQ TSPLLESQAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGK DANEVEKSESLKSAKIYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW BAA05548.1 Q28046 ADSV_BOVIN D26549 SCIN