| Identification |
|---|
| BMDB Protein ID
| BMDBP02749 |
| Secondary Accession Numbers
| None |
| Name
| Mitochondrial proton/calcium exchanger protein |
| Synonyms
|
Not Available
|
| Gene Name
| LETM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| LETM1 |
| Gene Sequence
|
>2199 bp
ATGGCGTCCATCTTACTGAGGAGTTGTCGCGGCCGCGGGCCCGCTCGCCTCCCGCCGCCC
CGCTCCGCCGCGCCGAGGGGTCCTGCTGGGGATCTGGCCTGCCTCAGTGGTGCCAGCGCT
GTGGGGTTGATGAGCTATGTGCCTCTTCCGTTGGGCAGCTGCGCTCCCGTCCGCCCCGTG
TACCTTTCCCTCCGCGCCGACCCCCTGGGCTGCTGGACACTGAGGCCCAAGCGCGCGTGC
GCGGTGCTTGCGGGGCCGAGGCTCCTCCCTGTGCGCTGCTGGCACTCCTCGCGCCCGCTG
GGCGATGACTCCGTGGTGGAGAAGTCCCTCCGGTCCCTCAAGGACAAGAACAAGAAGCTG
GAGGAAGGCGGCCCCGTGTATAGCCCGCCCGCACAGGCGGCGGTGAGGAAGCCCCTGGGG
CAGCGAGTCCTGGACGAGCTGAGGCACTACTACCACGGCTTCCGCCTGCTCTGGATCGAC
ACCAAGATCGCGGCGCGCATGCTCTGGCGCATCCTCCACGGCCACAGCCTGACCCGCCGC
GAGCGCAGGCAGTTCCTCCGCATCTGCGCCGACCTCTTCCGCCTGGTGCCCTTCCTGTTC
TTTGTGGTGGTGCCCTTCATGGAGTTCCTGCTGCCCGTCGCTGTGAAGCTCTTCCCCAAC
ATGCTGCCGTCCACGTTCGAGACCCAGTCCAGCAAGGAGGAGAGGCTGAAAAAGGAGCTG
CGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAGGACACCATTGAGGAGATGGCCCTGAAG
AACAAGGCTGCCAAGGGGAGCGCCACCAAAGACTTCTCCGTGTTCTTCCAGAAGATCCGA
GAGACGGGCGAGAGACCCAGCAACGAGGAAATCATGCGCTTTTCTAAGTTGTTTGAAGAT
GAGCTGACCCTGGACAACCTCACGCGCCCACAGCTGGTGGCGCTGTGCAAGCTGCTGGAG
CTGCAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTCACCATGAGGCTGCGCTCC
ATCAAGGCGGACGACAAGCTGATCGCTGAGGAGGGCGTGGACAGCCTGAACGTCAAGGAG
CTGCAGGCGGCGTGTCGGGCAAGAGGCATGCGGGCCCTGGGCGTCACAGAAGACCGCCTG
CGGGGCCAGCTGAAGCAGTGGCTGGAGCTGCACCTGCACCAGGAGATCCCGACGTCGCTG
CTCATCCTGTCCCGGGCCATGTACCTTCCCGAGACCCTGTCGCCTGCCGACCAGCTCAAG
TCTACCCTGCAGACCCTCCCAGAGATCGTGGCCAAGGAAGCCCAGGTGAAGGTGGCCGAG
GTGGAGGGTGAGCAGGTGGACAACAAGGCGAAGCTGGAGGCCACGCTGCAGGAGGAGGCG
GCCATCCAGCAGGAGCATCGCGAGAAGGAGCTGCAGCGGAAGAGCCAGGCGGCCGTGGCC
CAGGCAGCGAAGGAAGTGGAGCCCGAGGTGGTGGCCGAAGGTGCCCCGGGGAGGCCGGTG
GCTGAGCTGCAGCCAGAAGAGCCTGCTGTGACCCTCCCTTCCGAGGTCCTGAAGGACAGC
GCACCCGTCCTGGAAGGCTTGAAGGAAGAGGAAATAACTCAAGAGGAAATTGACGTACTC
AGCAATGCGTGCTCAAAACTGAAGGAGCAGAAGAAATCCCTGACGAAGGAGAAGGAGGAG
CTGGAGCTGCTAAAGGGGGACGTCCAGGACTACAGCCAGGATTTACAGGAGATCAAGAAG
GAACTTTCAAAGACTGGCGAAGAAATGTATGTGGAAGAGTCTAAAGCCAGCAAGAGGCTG
ACCAAGCGTGTGCAGCAAATGATCGGGCAGATGGACAGCCTGCTGGCGCAGCTGGAGGCC
GACCAGAAGGCGGGCAGGCTTGGCCCCGCCGCCGAGGCTGCGCCTGCAGGGGAGACGGTG
ATCAGCGTCTCTGAGCTCATCAACGCCATGAAGCAGATCAAGCACATTCCCGAGAGCAAG
CTGCTGAGCCTGGCCTCAGCCCTGGACGACAACAAGGATGGGAAGGTCGACATCGATGAT
CTCGTCAAGGTCATCGAGCTGGTGGACAAAGAAGACGTCCACATCTCCACCAGCCAGGTG
GCCGAGATCGTGGCCACGCTGGAGAAGGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAG
GAGAAGGCGGAGAAGGAGGCGGCCGAGGTGCAGAACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 732 |
| Molecular Weight
| 81818.0 |
| Theoretical pI
| 6.69 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>LETM1 and EF-hand domain-containing protein 1, mitochondrial
MASILLRSCRGRGPARLPPPRSAAPRGPAGDLACLSGASAVGLMSYVPLPLGSCAPVRPV
YLSLRADPLGCWTLRPKRACAVLAGPRLLPVRCWHSSRPLGDDSVVEKSLRSLKDKNKKL
EEGGPVYSPPAQAAVRKPLGQRVLDELRHYYHGFRLLWIDTKIAARMLWRILHGHSLTRR
ERRQFLRICADLFRLVPFLFFVVVPFMEFLLPVAVKLFPNMLPSTFETQSSKEERLKKEL
RVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFED
ELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKE
LQAACRARGMRALGVTEDRLRGQLKQWLELHLHQEIPTSLLILSRAMYLPETLSPADQLK
STLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQRKSQAAVA
QAAKEVEPEVVAEGAPGRPVAELQPEEPAVTLPSEVLKDSAPVLEGLKEEEITQEEIDVL
SNACSKLKEQKKSLTKEKEELELLKGDVQDYSQDLQEIKKELSKTGEEMYVEESKASKRL
TKRVQQMIGQMDSLLAQLEADQKAGRLGPAAEAAPAGETVISVSELINAMKQIKHIPESK
LLSLASALDDNKDGKVDIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAK
EKAEKEAAEVQN
|
| External Links |
|---|
| GenBank ID Protein
| AAI20275.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCA3 |
| UniProtKB/Swiss-Prot Entry Name
| LETM1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120274 |
| GeneCard ID
| LETM1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
