1.0 2018-05-07 22:33:06 UTC 2020-05-20 21:52:44 UTC BMDBP02767 Enzyme HOMER1 Cell cycle control, cell division, chromosome partitioning Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). BMDB0000464 Calcium 10 >1065 bp ATGGGGGAACAACCCATCTTCAGCACTCGAGCTCATGTCTTCCAGATCGACCCAAACACA AAGAAGAACTGGGTGCCCACCAGCAAGCATGCAGTTACTGTGTCTTATTTCTATGACAGC ACAAGAAACGTGTATAGGATAATCAGTTTAGACGGCTCAAAGGCAATAATTAACAGCACC ATCACTCCAAACATGACATTTACTAAAACATCTCAGAAGTTTGGCCAGTGGGCCGATAGC AGGGCAAACACTGTTTATGGACTGGGGTTCTCCTCTGAGCATCATCTTTCGAAATTTGCA GAAAAGTTTCAGGAATTTAAAGAAGCTGCTCGACTAGCAAAGGAGAAATCACAAGAAAAG ATGGAACTTACCAGTACACCTTCACAGGAATCAGCAGGTGGGGATCTTCAGTCTCCTTTA ACACCAGAAAGCATCAACGGGACAGATGATGAGAGAACACCTGATCTGACGCAGAACTCG GAGCCGCGGCCTGAACCCACCCAGAACGCACTGCCGTTCACACATAGTTCAGCAATCAGC AAACACTGGGAGGCTGAACTGGCCACCCTCAAAGGAAACAATGCCAAACTCACTGCAGCC CTGCTGGAGTCTACTGCCAATGTGAAACAATGGAAGCAGCAGCTTGCTGCCTATCAGGAG GAAGCAGAGCGGCTGCACAAGCGGGTGACTGAGCTTGAATGTGTTAGTAGCCAAGCAAAT GCAGTGCATACCCATAAGACAGAACTAAATCAGACAATACAAGAACTGGAGGAGACGCTG AAGGTGAAGGAAGAGGAAATAGAAAGATTAAAACAAGAAATTGATAATGCCAGAGAACTA CAAGAACAGAGGGACTCTTTGACTCAGAAACTACAGGAAGTAGAAATTCGGAACAAAGAC CTGGAGGGACAACTGTCTGACTTAGAGCAACGTCTGGAGAAAAGTCAGAATGAACAAGAA GCTTTTCGCAATAACCTGAAGACCCTGTTAGAAATCCTTGATGGAAAAATCTTTGAACTA ACAGAATTACGAGATAACTTGGCCAAGCTACTAGAACGCAGCTAA 354 40370.0 5.25 185-205 227-247 262-282 292-312 326-346 387-407 None >Homer protein homolog 1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDLTQNSEPRPEPTQNALPFTHSSAIS KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN AVHTHKTELNQTIQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD LEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLERS AAI05510.1 Q2KJ56 HOME1_BOVIN 1I2H BC105509 HOMER1