| Identification |
|---|
| BMDB Protein ID
| BMDBP02769 |
| Secondary Accession Numbers
| None |
| Name
| Gastrin/cholecystokinin type B receptor |
| Synonyms
|
Not Available
|
| Gene Name
| CCKBR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in gastrin receptor activity |
| Specific Function
| Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| CCKBR |
| Gene Sequence
|
>1365 bp
ATGGAGCTGCTAAAGCCAAACCGGAGCGTGCTGGGATCCGGACCCGGGCCGGGGGCTTCC
CTGTGCCGCTCGGGGGGCCCCCTCCTCAACGGCAGCGGCACCGGCAACCTCAGCTGTGAG
CCCCCACGCATCCGCGGAGCCGGGACACGAGAATTGGAGCTGGCCATTAGGGTCACCCTG
TATGCTGTGATCTTTCTGATGAGTGTTGGAGGAAACGTGCTCATCATCGTGGTCCTGGGG
CTGAGCCGCCGTCTGAGGACCGTCACCAATGCCTTCCTGCTCTCACTGGCAGTCAGCGAC
CTTCTGCTGGCTGTGGCTTGCATGCCCTTCACCCTCCTACCCAATCTCATGGGCACGTTT
ATCTTCGGCACAGTCGTCTGCAAGGCGGTTTCCTACTTCATGGGGGTGTCTGTGAGCGTG
TCCACGCTAAGCCTCGTGGCCATCGCCCTCGAGCGGTACAGCGCCATCTGCCGACCACTG
CAGGCACGCGTGTGGCAGACGCGCTCCCACGCGGCTCGTGTGATCGTAGCCACGTGGATG
CTGTCGGGACTGCTCATGGTGCCCTACCCAGTGTACACTGCCGTGCAGCCAGCGGGGCCT
CGTGTCTTGCAATGCATGCACCGGTGGCCCAGTGCGCGGGTTCGCCAAACCTGGTCGGTA
CTGCTGCTCCTGCTCTTGTTTTTCGTGCCTGGGGTGGTTATGGCGGTGGCCTACGGGCTT
ATCTCCCGTGAGCTCTACTTAGGGCTTCGCTTTGACGGTGACAGTGACAGCGAGAGCCAG
AGCCGGGTCGGAAGTCAGGGAGGGCTGCCCGGTGGCACAGGACAAGGTCCTGCCCAGGCG
AACGGACGTTGCCGGTCTGAGACCCGGCTGGCGGGTGAGGACGGCGACGGCTGTTATGTA
CAGCTTCCGCGCTCCCGGCCTGCATTGGAGATGTCTGCGCTGACCGCGCCCACGCCTGGC
CCAGGATCCGGCACCCGGCCTGCCCAGGCCAAGCTGCTGGCTAAGAAGCGCGTGGTGCGG
ATGTTACTGGTGATCGTTGTGCTTTTTTTCCTGTGTTGGTTGCCCGTGTATAGCGCCAAC
ACGTGGCGCGCCTTCGACGGCCCAGGCGCACATCGTGCACTTTCGGGTGCGCCCATCTCC
TTCATCCACTTGCTAACGTACGCCTCTGCCTGTGTCAACCCCCTGGTCTACTGCTTCATG
CACCGTCGCTTTCGCCAGGCCTGCCTTGACACCTGCACCCGCTGCTGTCCTCGGCCTCCA
AGGGCTCGCCCCAGACCTCTGCCGGACGAGGACCCTCCCACCCCCTCCATCGCCTCACTG
TCCAGGCTGAGCTATACCACCATCAGCACGCTGGGGCCTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 454 |
| Molecular Weight
| 48781.0 |
| Theoretical pI
| 10.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 58-79
- 88-109
- 132-150
- 171-189
- 220-242
- 341-362
- 381-401
|
| Protein Sequence
|
>Gastrin/cholecystokinin type B receptor
MELLKPNRSVLGSGPGPGASLCRSGGPLLNGSGTGNLSCEPPRIRGAGTRELELAIRVTL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVVCKAVSYFMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWM
LSGLLMVPYPVYTAVQPAGPRVLQCMHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYGL
ISRELYLGLRFDGDSDSESQSRVGSQGGLPGGTGQGPAQANGRCRSETRLAGEDGDGCYV
QLPRSRPALEMSALTAPTPGPGSGTRPAQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSAN
TWRAFDGPGAHRALSGAPISFIHLLTYASACVNPLVYCFMHRRFRQACLDTCTRCCPRPP
RARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
|
| External Links |
|---|
| GenBank ID Protein
| AAB46896.1 |
| UniProtKB/Swiss-Prot ID
| P79266 |
| UniProtKB/Swiss-Prot Entry Name
| GASR_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| S83090 |
| GeneCard ID
| CCKBR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
