| Identification |
|---|
| BMDB Protein ID
| BMDBP02804 |
| Secondary Accession Numbers
| None |
| Name
| S-arrestin |
| Synonyms
|
Not Available
|
| Gene Name
| SAG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (PubMed:8003967, PubMed:25205354). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| SAG |
| Gene Sequence
|
>1215 bp
CGGCAGCCAGTATGAAGGCCAATAAGCCCGCACCAAACCACGTTATCTTCAAGAAGATCT
CCCGTGATAAATCGGTGACCATCTACCTGGGGAAGAGAGATTACATAGACCACGTTGAAC
GAGTAGAGCCTGTGGATGGCGTCGTGCTGGTGGATCCTGAGCTCGTGAAGGGCAAGAGAG
TGTACGTGTCTCTGACGTGTGCCTTCCGCTACGGCCAGGAAGACATCGACGTGATGGGCC
TCAGCTTCCGCAGGGACCTCTACTTCTCCCAGGTCCAGGTGTTCCCTCCCGTGGGGGCCT
CGGGCGCCACCACGAGGCTGCAGGAGAGCCTCATCAAGAAGCTGGGGGCCAACACCTACC
CCTTCCTGCTCACGTTTCCTGACTACTTGCCCTGTTCGGTGATGCTGCAGCCAGCTCCGC
AAGATGTGGGCAAGAGCTGTGGGGTCGACTTTGAGATCAAAGCATTCGCCACGCACAGCA
CAGATGTGGAAGAGGACAAAATTCCCAAGAAGAGCTCCGTGCGTTTGCTGATCCGGAAGG
TACAGCACGCGCCACGCGATATGGGTCCCCAGCCCCGAGCCGAGGCCTCCTGGCAGTTCT
TCATGTCGGACAAGCCCCTGCGCCTCGCCGTCTCGCTCAGCAAAGAGATCTATTACCACG
GGGAACCCATTCCTGTGACCGTGGCCGTGACCAACAGCACAGAGAAGACAGTGAAGAAGA
TTAAAGTGCTAGTGGAGCAAGTGACCAACGTGGTTCTCTACTCGAGTGATTATTACATCA
AGACGGTGGCTGCCGAGGAAGCACAGGAAAAAGTGCCGCCAAACAGCTCGCTGACCAAGA
CGCTGACGCTGGTGCCCTTGCTGGCCAACAACCGTGAGAGAAGGGGCATCGCCCTGGATG
GGAAAATCAAGCACGAGGACACGAACCTGGCCTCCAGCACCATCATAAAGGAGGGAATAG
ACAAGACCGTCATGGGGATCCTGGTGTCTTACCAGATCAAGGTGAAGCTCACGGTGTCAG
GCCTTCTGGGAGAGCTCACATCCAGTGAAGTGGCCACTGAGGTGCCGTTCCGCCTCATGC
ATCCCCAGCCAGAGGACCCAGATACCGCCAAGGAAAGTTTTCAGGATGAAAATTTTGTTT
TTGAGGAGTTTGCTCGCCAAAATCTGAAAGATGCAGGAGAATATAAGGAAGAGAAGACAG
ACCAGGAGGCGGCTA
|
| Protein Properties |
|---|
| Number of Residues
| 404 |
| Molecular Weight
| 45275.0 |
| Theoretical pI
| 6.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 318-338
- 354-374
- 386-404
- 463-484
- 504-526
- 554-575
- 587-609
|
| Protein Sequence
|
>S-arrestin
MKANKPAPNHVIFKKISRDKSVTIYLGKRDYIDHVERVEPVDGVVLVDPELVKGKRVYVS
LTCAFRYGQEDIDVMGLSFRRDLYFSQVQVFPPVGASGATTRLQESLIKKLGANTYPFLL
TFPDYLPCSVMLQPAPQDVGKSCGVDFEIKAFATHSTDVEEDKIPKKSSVRLLIRKVQHA
PRDMGPQPRAEASWQFFMSDKPLRLAVSLSKEIYYHGEPIPVTVAVTNSTEKTVKKIKVL
VEQVTNVVLYSSDYYIKTVAAEEAQEKVPPNSSLTKTLTLVPLLANNRERRGIALDGKIK
HEDTNLASSTIIKEGIDKTVMGILVSYQIKVKLTVSGLLGELTSSEVATEVPFRLMHPQP
EDPDTAKESFQDENFVFEEFARQNLKDAGEYKEEKTDQEAAMDE
|
| External Links |
|---|
| GenBank ID Protein
| AAA30378.1 |
| UniProtKB/Swiss-Prot ID
| P08168 |
| UniProtKB/Swiss-Prot Entry Name
| ARRS_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| J02955 |
| GeneCard ID
| SAG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
