| Identification |
|---|
| BMDB Protein ID
| BMDBP02814 |
| Secondary Accession Numbers
| None |
| Name
| Calcium uptake protein 1, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| MICU1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| MICU1 |
| Gene Sequence
|
>1437 bp
ATGTTTCGTCTTAACTCACTTTCTGCGTTGGCAGAGCTGGCAGTGGGCTCTCGATGGTAC
CATGGAGGATCACAGCCCACCCAGATCAGGCGACGGCTAATGATGGTGGCTTTTCTTGGA
GCATCTGCAGTAACTGCAAGTACTGGTCTGTTGTGGAAAAGGGCCCTTGCAGAATCTCCA
CCATCTGCAAACAACATCAAGAGTGAACTTGGAGATAAAGGGAAGAGTAAAGAGGAAGGG
GAAGATTGTAATGCTGAAAAAAAGGCTGCAGGTGTTTGTCTTGAGCCGTATCCAGAAGAG
AAAAAGAAGAAACGTTCTGGATTCAGAGATAGAAAAGTGATGGAATATGAGAATAGGATT
CGTGCATATTCCACACCAGATAAAATCTTCCGCTATTTTGCCACCTTGAAAGTAATCAGT
GAGCATGGTGAATCTGAAGTGTTTATGACACCACAAGATTTTGTGCGATCCATAACACCC
AATGAAAAACAACCAGAACACTTGGGTCTGGATCAATATACAATAAAACGCTTTGATGGA
AAGAAAATTGCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTT
GGAGAATGTGGACTTATATCCTTTTCAGACTACATTTTCCTTACGACTGTTCTTTCGACT
CCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGACTTGAATGGAGATGGAGAAGTA
GACATGGAAGAGTTTGAACAGGTTCAGAGCATTATTCGCTCCCAAACCAGCATGGGAATG
CGTCACAGAGATCGTTCTACAACTGGTAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTC
ACAACCTACTTTTTTGGAGCTGATCTTAAGGGGAAGCTGACAATCAAAAACTTCCTTGAA
TTTCAGCGTAAACTGCAGCACGATGTTCTGAAGCTGGAGTTTGAACGCCATGACCCTGTG
GATGGGAGAATCACTGAGAGGCAGTTTGGTGGCATGCTGCTGGCTTACAGTGGAGTGCAG
TCCAAGAAGTTGACTGCCATGCAGAAGCAGCTCAAGAAGCACTTCAAAGAGGGAAAGGGG
CTGACATTTCAGGAAGTGGAGAACTTCTTTACCTTCCTAAAGAATATTAATGATGTAGAC
ACTGCATTGAGCTTTTACCATATGGCTGGGGCATCTCTTGATAAAGTGACCATGCAGCAG
GTAGCCAGGACAGTGGCTAAAGTGGAACTCTCAGATCACGTGTGCGATGTGGTGTTTGCG
CTCTTTGACTGTGATGGCAATGGAGAGCTGAGCAATAAGGAATTTGTTTCTATCATGAAG
CAACGGCTGATGAGAGGCTTGGAGAAGCCCAAAGACATGGGCTTCACCCGCCTCATGCAG
GCCATGTGGAAATGTGCACAGGAGACTGCCTGGGACTTCGCTTTGCCCAAACAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 478 |
| Molecular Weight
| 54422.0 |
| Theoretical pI
| 8.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-binding atopy-related autoantigen 1
MFRLNSLSALAELAVGSRWYHGGSQPTQIRRRLMMVAFLGASAVTASTGLLWKRALAESP
PSANNIKSELGDKGKSKEEGEDCNAEKKAAGVCLEPYPEEKKKKRSGFRDRKVMEYENRI
RAYSTPDKIFRYFATLKVISEHGESEVFMTPQDFVRSITPNEKQPEHLGLDQYTIKRFDG
KKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQVQSIIRSQTSMGMRHRDRSTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLE
FQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQKQLKKHFKEGKG
LTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA
LFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPKQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI22591.1 |
| UniProtKB/Swiss-Prot ID
| Q0IIL1 |
| UniProtKB/Swiss-Prot Entry Name
| MICU1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122590 |
| GeneCard ID
| MICU1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
