Identification
BMDB Protein ID BMDBP02818
Secondary Accession Numbers None
Name RAS guanyl-releasing protein 2
Synonyms Not Available
Gene Name RASGRP2
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
Pathways
  • Ras Signaling Pathway
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 29
Locus Not Available
SNPs RASGRP2
Gene Sequence Not Available
Protein Properties
Number of Residues 608
Molecular Weight 69180.0
Theoretical pI 7.6
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>RAS guanyl-releasing protein 2
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY
QQSRKDNSSSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID
IENVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPLELAAHLTYLEYRSFCKILFQDYHS
FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRAGVITHFVHVAEELLHLQNF
NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR
FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL
LSLLMVSLDQYQTEDELYQLSLQREPRSKSSPTSPTTCTPPPRPPVLEEWTSAAKPKLDQ
AIMVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISKEEM
VSYFLRSSSMLGGRMGFVHNFHESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC
KDRLSVECRRRAQSMSLEGSAPSPSPTHTHHRAFSFSLPRPGRRGSRPPEIREEEVQTVE
DGVFDIHL
GenBank ID Protein ABR27454.1
UniProtKB/Swiss-Prot ID A6N9I4
UniProtKB/Swiss-Prot Entry Name GRP2_BOVIN
PDB IDs Not Available
GenBank Gene ID EF633475
GeneCard ID RASGRP2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available