Identification
BMDB Protein ID BMDBP02992
Secondary Accession Numbers None
Name Patatin-like phospholipase domain-containing protein 2
Synonyms Not Available
Gene Name PNPLA2
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
Pathways Not Available
Reactions
Retinyl ester + DG(16:1(9Z)/22:0/0:0) → Vitamin A + TG(16:1(9Z)/22:0/16:1(9Z)) details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs PNPLA2
Gene Sequence Not Available
Protein Properties
Number of Residues 486
Molecular Weight 53417.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 9-29
Protein Sequence Not Available
GenBank ID Protein AAI12804.1
UniProtKB/Swiss-Prot ID Q2KI18
UniProtKB/Swiss-Prot Entry Name PLPL2_BOVIN
PDB IDs Not Available
GenBank Gene ID BC112803
GeneCard ID PNPLA2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available