Showing Protein Phospholipase A2 group XV (BMDBP03193)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP03193 |
| Secondary Accession Numbers |
|
| Name | Phospholipase A2 group XV |
| Synonyms | Not Available |
| Gene Name | PLA2G15 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796, PubMed:9525960). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:11790796, PubMed:9525960). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (By similarity). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | PLA2G15 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 407 |
| Molecular Weight | 46062.0 |
| Theoretical pI | Not Available |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence | Not Available |
| External Links | |
| GenBank ID Protein | AAL65270.1 |
| UniProtKB/Swiss-Prot ID | Q8WMP9 |
| UniProtKB/Swiss-Prot Entry Name | PAG15_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AY072914 |
| GeneCard ID | PLA2G15 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |