| Identification |
|---|
| BMDB Protein ID
| BMDBP00080 |
| Secondary Accession Numbers
| None |
| Name
| Galactosylceramide sulfotransferase |
| Synonyms
|
Not Available
|
| Gene Name
| GAL3ST1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosylceramide sulfotransferase activity |
| Specific Function
| Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3-galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (By similarity). |
| Pathways
|
- Lipid metabolism
- Sphingolipid Metabolism
|
| Reactions
|
| Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate → 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate |
details
|
| Galabiosylceramide (d18:1/22:0) + Phosphoadenosine phosphosulfate → Galabiosylceramide-sulfate + Adenosine 3',5'-diphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| GAL3ST1 |
| Gene Sequence
|
>1272 bp
ATGCCGCTGCCACAGAAGAAGCGCTGGGAGTCCATGGCCAAGGGGCTGGTGCTGGGAGCG
CTCTTCACCAGCTTCCTGCTACTGCTGTACTCCTATGCTGTCCCCCCACTGTACACTGGC
CTGGCTTCCACGACCCCCGAGGGCGCGGCACCCTGCTCTCCGGCCCCGAGGGAGCCAGAG
GCTCCCACCTCGGCCAACGGCTCGGCGGGAGGCTGCCAGCCGCGGCGGGACATCGTGTTC
ATGAAGACGCACAAGACGGCCAGCAGCACGCTGCTCAACATCCTGTTCCGCTTCGGCCAG
AAGCACGGGCTCAAGTTCGCCTTCCCCAACGGCCGCAACGACTTCGACTACCCCGCCTTC
TTCGCGCGCAGCCTGGTGCAGGACTACCGGCCCGGGGCCTGCTTCAACATCATCTGCAAC
CACATGCGCTTCCACTACGACGAGGTGCGGGGCCTGGTGGCGCCCAACGCCACCTTCATC
ACCGTGCTGCGCGACCCCGCCCGCCTCTTCGAGTCCTCCTTCCACTACTTCGGCTCCGTG
GTGCCCTTCACGTGGAAGCTCTCGGGCCGCGACAAGCTGGCCGAGTTCCTGCAGGACCCC
GACCGCTACTACGACGCCCGCGGCTACAACGCCCACTACCTCCGCAACCTGCTCTTCTTC
GACCTGGGCTACGACAGCGACCTGGACCCCAGCAGCCCGCAGGTGCAGGAGCACATCCTG
GAGGTGGAGCGCCACTTCCACCTGGTGCTGCTGCAGGAGTACTTCGACGAGTCGCTCGTG
CTGCTCAAGGACCTGCTGTGCTGGGAGCTGGAGGACGTGCTCTACTTCAAGCTCAACGCC
CGCCGCGCCTCGGCCGTGCCGCGCCTCTCGGGCGAGCTGTACCGGCGCGCCACGGCCTGG
AACGTGCTGGACGCGCGCCTCTACCGCCACTTCAACGCCAGCTTCTGGCGCAAGGTGGAG
GCCTTCGGGCGCGAGCGCATGGCCCGCGAGGTGGCCGCCCTGCGGCGCGCCAACGAGCGC
ATGCGCCGCATCTGCATCGACGGCGGCCGCGCGGTGGACGCGGCGGCCATCGAGGACTCG
GCCATGCAGCCCTGGCAGCCGCTGGGCGCCAAGTCCATCCTGGGCTACAACCTCAAGAAG
AGCATCGGGCAGCGGCATGCGCAGCTCTGCCGGCGCATGCTCACGCCGGAGATCCAGTAC
CTGATGGACCTGGGCGCCAACCTGTGGATCACCAAGCTCTGGAAGTTCATCCGGGACTTC
CTGCGGTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 423 |
| Molecular Weight
| 48754.0 |
| Theoretical pI
| 9.53 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Galactosylceramide sulfotransferase
MPLPQKKRWESMAKGLVLGALFTSFLLLLYSYAVPPLYTGLASTTPEGAAPCSPAPREPE
APTSANGSAGGCQPRRDIVFMKTHKTASSTLLNILFRFGQKHGLKFAFPNGRNDFDYPAF
FARSLVQDYRPGACFNIICNHMRFHYDEVRGLVAPNATFITVLRDPARLFESSFHYFGSV
VPFTWKLSGRDKLAEFLQDPDRYYDARGYNAHYLRNLLFFDLGYDSDLDPSSPQVQEHIL
EVERHFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRASAVPRLSGELYRRATAW
NVLDARLYRHFNASFWRKVEAFGRERMAREVAALRRANERMRRICIDGGRAVDAAAIEDS
AMQPWQPLGAKSILGYNLKKSIGQRHAQLCRRMLTPEIQYLMDLGANLWITKLWKFIRDF
LRW
|
| External Links |
|---|
| GenBank ID Protein
| AAI48871.1 |
| UniProtKB/Swiss-Prot ID
| A6QNK1 |
| UniProtKB/Swiss-Prot Entry Name
| G3ST1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC148870 |
| GeneCard ID
| GAL3ST1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
