| Identification |
|---|
| BMDB Protein ID
| BMDBP00906 |
| Secondary Accession Numbers
| None |
| Name
| Methylenetetrahydrofolate reductase |
| Synonyms
|
Not Available
|
| Gene Name
| MTHFR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. |
| Pathways
|
- Folate Metabolism
- Methionine Metabolism
- One-carbon metabolism
- Tetrahydrofolate interconversion
|
| Reactions
|
| 5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| MTHFR |
| Gene Sequence
|
>1968 bp
ATGGTGAACGAACCCAGAGGGAACGGCAGCCCCGGCCCCCGCTGGGAGGGCAGCAGCAGC
GGCAGCGAGAGCTCAAGGACAAGTTCAAGGTGCTCCACGCCGGGGTTGGACCCCGAGCGA
TGCGAGAGACTCCGGGAGAAGATGAAGCGGAAGATGGACTCTGGAGACAAGTGGTTCTCC
CTAGAGTTCTTCCCTCCCCGAACTGCCCAGGGTGCTGTCAATCTCATCTCCAGGTTTGAC
CGGATGGGAGCGGGTGGCCCCCTCTTTGTAGACGTGACCTGGCACCCAGCCGGGGATCCT
GGCTCCGACAAGGAGACCTCGTCCATGGTGATTGCCAGCACTGCCGTGAACTACTGCGGC
CTCGAGACAATCCTGCACATGACCTGCTGCCATCAGAGCCGTGAAGAGATCACGGGCCAC
CTGAACAAAGCCAAGCAGCTGGGCCTGAAGAACATCCTGGCGCTGAGGGGAGACCCCATA
GGTGACCAATGGGAAGAGGAGGAAGGAGGCTTCAACTATGCTACGGACTTGGTGAAGCAC
ATCCGAAACGAGTTTGGTGACTACTTTGACGTCTGTGTGGCAGGTTACCCCAAAGGCCAC
CCTGAAGGAGAGAGCTTTGAGGCTGATCTGAAGCACCTGAAGGAGAAGGTGGCTGCAGGA
GCCGACTTCATCATCACCCAGCTATTCTTTGAGGCTGAAACATTCTTCCGCTTTGTGAAG
GCTTGCTCCGAGATAGGCATTACCTGCCCCGTCCTCCCCGGCATCTTCCCAATTCAGGGC
TACCACTCCCTCCGGCAGCTGGTGAAACTGTCCAAACTGGAGGTGCCACAGCAGATCAAG
GATGTGATCGAGCCCATCAAAGACAATGATGCTGCCATCCGCAACTATGGCATCGAGCAG
GCCGTGAGCCTGTGCCAGGAGCTGCTGGCCAGTGGCTTGGTTCCAGGCCTCCACTTCTAC
ACCCTCAACCGCGAGGTGGCCACCATCGAGGTGCTGAAGCGCCTGGGGCTTTGGATTGAG
GACCCTAGGCGTCCCCTGCCCTGGGCCCTCAGTGCCCACCCCAAGCGCCGGGTGGAGGAT
GTCCGGCCCATCTTCTGGGCCTCGAGACCAAAGAGTTACATTTACCGTACGCAGGAGTGG
GACGAGTTCCCCAATGGCCGCTGGGGCAATTCCTCCTCTCCGGCCTTTGGGGAGCTGAAG
GACTACTACCTCTTCTACCTAAAGAGCAAGTCCCCGAAGGAGGAGCTGCTCAAGATGTGG
GGGGAGGAGCTGACCAGTGAGGAAAGCGTCTTCCAAGTCTTTGCCCACCACCTCTCGGGA
GAGCCCAACCAGAATGGCTACAAAGTGACTTGCCTGCCCTGGAATGATGAGCCCCTGGCA
GCCGAGACCAGCCTGATGAAGGAGGAGCTGCTGAGAGTGAACCGGCGAGGCATCCTCACC
ATCAACTCCCAGCCCAACATCAACGGGAAGCCGTCCTCTGACCCCATCGTGGGCTGGGGC
CCCAGTGGGGGCTATGTCTTCCAGAAGGCCTACTTAGAGTTCTTCACTTCCCGAGAAACG
GTGGAGGCGCTTTTGCAGGTGCTGAAGAAGTATGAACTCCGGGTGAATTACCACATCGTG
GATGTGAAGGGTGAAAATATCACCAACGCCCCTGAGCTGCAACCCAACGCGGTCACCTGG
GGCATCTTCCCTGGCCGAGAGATCATCCAGCCCACAGTGGTGGACCCGGTCAGCTTCATG
TTCTGGAAGGATGAGGCCTTCGCGCTGTGGATTGAGCAGTGGGGCAAGCTGTATGAGGAG
GAGTCCCCCTCCCGCATGATCATCCAGTACATCCACGACAACTACTTCCTGGTCAACCTG
GTGGACAACGAGTTTCCGCTGGACAACTGCCTGTGGCAGGTGGTGGAAGACACGTTTGAG
CTTCTCAGCAGGCCCCCCCAAGACAAGAGGGAGACAGAGGCGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 655 |
| Molecular Weight
| 74485.0 |
| Theoretical pI
| 5.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methylenetetrahydrofolate reductase
MVNEPRGNGSPGPRWEGSSSGSESSRTSSRCSTPGLDPERCERLREKMKRKMDSGDKWFS
LEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPGSDKETSSMVIASTAVNYCG
LETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPIGDQWEEEEGGFNYATDLVKH
IRNEFGDYFDVCVAGYPKGHPEGESFEADLKHLKEKVAAGADFIITQLFFEAETFFRFVK
ACSEIGITCPVLPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQ
AVSLCQELLASGLVPGLHFYTLNREVATIEVLKRLGLWIEDPRRPLPWALSAHPKRRVED
VRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMW
GEELTSEESVFQVFAHHLSGEPNQNGYKVTCLPWNDEPLAAETSLMKEELLRVNRRGILT
INSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKKYELRVNYHIV
DVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEE
ESPSRMIIQYIHDNYFLVNLVDNEFPLDNCLWQVVEDTFELLSRPPQDKRETEAL
|
| External Links |
|---|
| GenBank ID Protein
| AAW39033.1 |
| UniProtKB/Swiss-Prot ID
| Q5I598 |
| UniProtKB/Swiss-Prot Entry Name
| MTHR_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY854631 |
| GeneCard ID
| MTHFR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
