| Identification |
|---|
| BMDB Protein ID
| BMDBP01865 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit alpha-2 |
| Synonyms
|
Not Available
|
| Gene Name
| GABRA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2842688). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| GABRA2 |
| Gene Sequence
|
>1356 bp
ATGAAGACGAAACTGAACAGCTCCAATATGCAGTTGCTGCTTTTTGTTTTCTTGGCGTGG
GATCCAGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC
ATCTTTACAAGAATTCTAGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA
CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTATGTGACCAGTTTTGGCCCTGTC
TCAGATACAGACATGGAATATACAATCGATGTTTTCTTTCGACAAAAATGGAAAGATGAA
CGATTAAAATTTAAAGGTCCTATGAACATCCTTCGACTCAACAATTTAATGGCCAGCAAA
ATCTGGACTCCAGATACCTTTTTCCACAATGGGAAGAAATCGGTGGCACACAATATGACA
ATGCCAAATAAGCTTCTCCGAATCCAGGATGATGGGACCCTGCTGTACACAATGAGGCTT
ACAGTTCAAGCTGAATGTCCAATGCACTTGGAGGATTTTCCAATGGATGCCCACTCATGT
CCTCTGAAATTTGGCAGCTATGCATATACAACCTCAGAGGTTACTTACATTTGGACATAC
AATGCGTCTGATTCTGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGATCTG
CCGGGCCAATCAATTGGGAAGGAGACAATTAAATCTAGTACAGGTGAATATACCGTAATG
ACAGCTCATTTCCACTTGAAAAGAAAAATTGGATATTTTGTGATTCAGACATATCTGCCT
TGCATCATGACTGTCATTCTCTCCCAAGTGTCATTCTGGCTTAACAGAGAATCTGTGCCT
GCAAGAACAGTGTTTGGAGTAACAACTGTTCTAACAATGACAACTCTAAGCATCAGTGCT
CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGC
TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA
GGATGGGCTTGGGATGGAAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAAGCCTCTGTG
ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA
GACCCAGTTCTCTCCACCATCTCCAAGAGCGCAACCACTCCAGAACCCAACAAGAAACCG
GAAAACAAGCCAGCCGAAGCCAAGAAGACCTTCAATAGCGTTAGCAAAATTGACAGAATG
TCTAGAATAGTTTTCCCAGTTTTGTTTGGTACATTTAATTTAGTTTACTGGGCCACATAT
TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 451 |
| Molecular Weight
| 51146.0 |
| Theoretical pI
| 9.51 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 252-273
- 279-300
- 313-334
- 420-441
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit alpha-2
MKTKLNSSNMQLLLFVFLAWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLPGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
|
| External Links |
|---|
| GenBank ID Protein
| CAA30924.1 |
| UniProtKB/Swiss-Prot ID
| P10063 |
| UniProtKB/Swiss-Prot Entry Name
| GBRA2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X12361 |
| GeneCard ID
| GABRA2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
