Showing metabocard for Phosphoadenosine phosphosulfate (BMDB0001134)

General function:

Involved in galactosylceramide sulfotransferase activity

Specific function:

Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3-galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (By similarity).

Gene Name:

GAL3ST1

Uniprot ID:

A6QNK1

Molecular weight:

48754.0

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General function:

Carbohydrate transport and metabolism

Specific function:

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 (By similarity).

Gene Name:

BPNT1

Uniprot ID:

Q3ZCK3

Molecular weight:

33328.0

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General function:

Involved in protein-tyrosine sulfotransferase activity

Specific function:

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Gene Name:

TPST2

Uniprot ID:

Q3SYY2

Molecular weight:

41967.0

General function:

Involved in aryl sulfotransferase activity

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).

Gene Name:

SULT1A1

Uniprot ID:

P50227

Molecular weight:

34184.0

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General function:

Involved in [heparan sulfate]-glucosamine N-sulfotransf

Specific function:

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).

Gene Name:

NDST2

Uniprot ID:

O97583

Molecular weight:

100897.0

General function:

Involved in estrone sulfotransferase activity

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity).

Gene Name:

SULT1E1

Uniprot ID:

P19217

Molecular weight:

34640.0

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General function:

Not Available

Specific function:

Not Available

Gene Name:

PAPSS2

Uniprot ID:

Q0VC88

Molecular weight:

69672.0

Reactions