Showing metabocard for Inositol 1,4,5-trisphosphate (BMDB0001498)

General function:

Cell cycle control, cell division, chromosome partitioning

Specific function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Gene Name:

PLCB1

Uniprot ID:

P10894

Molecular weight:

138715.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).

Gene Name:

PLCD4

Uniprot ID:

P21671

Molecular weight:

90581.0

General function:

Involved in calcium ion binding

Specific function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Gene Name:

PLCZ1

Uniprot ID:

Q1RML2

Molecular weight:

73732.0

General function:

Involved in calcium ion binding

Specific function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.

Gene Name:

PLCD1

Uniprot ID:

P10895

Molecular weight:

86073.0

General function:

Involved in calcium ion binding

Specific function:

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).

Gene Name:

PLCG1

Uniprot ID:

P08487

Molecular weight:

148313.0

General function:

Replication, recombination and repair

Specific function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.

Gene Name:

PLCB4

Uniprot ID:

Q07722

Molecular weight:

117110.0

General function:

Involved in actin binding

Specific function:

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).

Gene Name:

MYO1C

Uniprot ID:

Q27966

Molecular weight:

121936.0

General function:

Involved in calcium ion binding

Specific function:

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:11584008). This release is regulated by cAMP both dependently and independently of PKA (By similarity).

Gene Name:

ITPR2

Uniprot ID:

Q8WN96

Molecular weight:

307820.0

General function:

Involved in G-protein coupled receptor protein signalin

Specific function:

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Gene Name:

PTGDR

Uniprot ID:

A5D7K8

Molecular weight:

40372.0

General function:

Not Available

Specific function:

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).

Gene Name:

ERLIN2

Uniprot ID:

Q1RMU4

Molecular weight:

37730.0

General function:

Involved in calcium ion binding

Specific function:

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Gene Name:

ITPR1

Uniprot ID:

Q9TU34

Molecular weight:

308318.0

General function:

Involved in calcium ion binding

Specific function:

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

Gene Name:

ITPR3

Uniprot ID:

Q8WN95

Molecular weight:

303040.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

IPMK

Uniprot ID:

F1N1W2

Molecular weight:

47029.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

MINPP1

Uniprot ID:

Q2TBT6

Molecular weight:

41435.0

Reactions

General function:

Not Available

Specific function:

Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (PubMed:9199318).

Gene Name:

SYNJ1

Uniprot ID:

O18964

Molecular weight:

146584.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

ITPKA

Uniprot ID:

A4FV33

Molecular weight:

50689.0

Reactions